Maraki, Maria I., Hatzimanolis, Alexandros, Mourtzi, Niki, Stefanis, Leonidas, Yannakoulia, Mary ORCID: 0000-0003-2171-7337, Kosmidis, Mary H., Dardiotis, Efthimios, Hadjigeorgiou, Georgios M., Sakka, Paraskevi, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Grenier-Boley, Benjamin, Lambert, Jean-Charles, Heilmann-Heimbach, Stefanie, Stamelou, Maria, Scarmeas, Nikolaos and Xiromerisiou, Georgia (2021). Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson's Disease in Older Adults. Front. Molec. Neurosci., 14. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5099

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Abstract

Several studies have investigated the association of the Parkinson's disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage of PD. We calculated PRS in a longitudinal sample (n = 1120) of community dwelling individuals >= 65 years from the HELIAD (The Hellenic Longitudinal Investigation of Aging and Diet) study in order to evaluate the association of this score with the probability of prodromal PD or any of the established risk and prodromal markers in MDS research criteria, using regression multi-adjusted models. Increases in PRS estimated from GWAS summary statistics' ninety top SNPS with p < 5 x 10(-8) was associated with increased odds of having probable/possible prodromal PD (i.e., >= 30% probability, OR = 1.033, 95%CI: 1.009-1.057 p = 0.006). From the prodromal PD risk markers, significant association was found between PRS and global cognitive deficit exclusively (p = 0.003). To our knowledge, our study is the first population based study investigating the association between PRS scores and prodromal markers of Parkinson's disease. Our results suggest a strong relationship between the accumulation of many common genetic variants, as measured by PRS, and cognitive deficits.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Maraki, Maria I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatzimanolis, AlexandrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourtzi, NikiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefanis, LeonidasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yannakoulia, MaryUNSPECIFIEDorcid.org/0000-0003-2171-7337UNSPECIFIED
Kosmidis, Mary H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dardiotis, EfthimiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hadjigeorgiou, Georgios M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakka, ParaskeviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Grenier-Boley, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambert, Jean-CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heilmann-Heimbach, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stamelou, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scarmeas, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xiromerisiou, GeorgiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604435
DOI: 10.3389/fnmol.2021.739571
Journal or Publication Title: Front. Molec. Neurosci.
Volume: 14
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1662-5099
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MDS RESEARCH CRITERIA; GENOME-WIDE ASSOCIATION; COGNITIVE PERFORMANCE; DEMENTIA; METAANALYSIS; VALIDATION; MANAGEMENT; IMPUTATION; BIOMARKER; DECLINEMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60443

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