Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Vestentoft, Pia Siig, Brand-Miller, Jennie C., Jalo, Elli, Westerterp-Plantenga, Margriet, Simpson, Elizabeth J., Handjieva-Darlenska, Teodora, Stratton, Gareth, Huttunen-Lenz, Maija ORCID: 0000-0002-1034-1613, Lam, Tony, Muirhead, Roslyn, Poppitt, Sally, Pietilainen, Kirsi H., Adam, Tanja, Taylor, Moira A., Handjiev, Svetoslav, McNarry, Melitta A., Hansen, Sylvia, Brodie, Shannon, Silvestre, Marta P., Macdonald, Ian A., Boyadjieva, Nadka, Mackintosh, Kelly A., Schlicht, Wolfgang, Liu, Amy, Larsen, Thomas M., Fogelholm, Mikael, Raben, Anne ORCID: 0000-0001-5229-4491 and Alfredo Martinez, J. (2021). Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial. Front. Nutr., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-861X

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Abstract

Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) x fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve >= 8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Navas-Carretero, SantiagoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
San-Cristobal, RodrigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vestentoft, Pia SiigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brand-Miller, Jennie C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jalo, ElliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westerterp-Plantenga, MargrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simpson, Elizabeth J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handjieva-Darlenska, TeodoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stratton, GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huttunen-Lenz, MaijaUNSPECIFIEDorcid.org/0000-0002-1034-1613UNSPECIFIED
Lam, TonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muirhead, RoslynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poppitt, SallyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pietilainen, Kirsi H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adam, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, Moira A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Handjiev, SvetoslavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McNarry, Melitta A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodie, ShannonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silvestre, Marta P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macdonald, Ian A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boyadjieva, NadkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mackintosh, Kelly A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlicht, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larsen, Thomas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fogelholm, MikaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raben, AnneUNSPECIFIEDorcid.org/0000-0001-5229-4491UNSPECIFIED
Alfredo Martinez, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604502
DOI: 10.3389/fnut.2021.733697
Journal or Publication Title: Front. Nutr.
Volume: 8
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2296-861X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FASTING PLASMA-GLUCOSE; WEIGHT-LOSS; PERSONALIZED NUTRITION; RISK-FACTORS; TYG INDEX; EXERCISE; DIET; ASSOCIATION; POPULATION; PREVENTIONMultiple languages
Nutrition & DieteticsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60450

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