Oeztuerk, Oemer Faruk, Pigoni, Alessandro, Wenzel, Julian, Haas, Shalaila S., Popovic, David, Ruef, Anne, Dwyer, Dominic B., Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Lalousis, Paris, Griffiths, Sian Lowri, Lichtenstein, Theresa, Rosen, Marlene, Kambeitz, Joseph, Schultze-Lutter, Frauke, Liddle, Peter, Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Salokangas, Raimo K. R., Pantelis, Christos ORCID: 0000-0002-9565-0238, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Falkai, Peter, Antonucci, Linda A. and Koutsouleris, Nikolaos (2022). The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study. Eur. Arch. Psych. Clin. Neurosci., 272 (3). S. 403 - 414. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Background Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. Methods 279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Results The results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (p(fdr) < 0.001) and role (p(fdr) < 0.001) functioning, as well as worse neurocognitive performance in semantic (p(fdr) < 0.001) and phonological verbal fluency (p(fdr) < 0.001), short-term verbal memory (p(fdr) = 0.002) and abstract thinking (p(fdr) = 0.010), in comparison to FTD-Low group. Conclusions Clustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Oeztuerk, Oemer FarukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pigoni, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, Shalaila S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popovic, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, Dominic B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chisholm, KatharineUNSPECIFIEDorcid.org/0000-0002-0575-0789UNSPECIFIED
Lalousis, ParisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griffiths, Sian LowriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtenstein, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liddle, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604647
DOI: 10.1007/s00406-021-01327-y
Journal or Publication Title: Eur. Arch. Psych. Clin. Neurosci.
Volume: 272
Number: 3
Page Range: S. 403 - 414
Date: 2022
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1433-8491
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIGH-RISK; R-PACKAGE; FOLLOW-UP; SCHIZOPHRENIA; LANGUAGE; ONSET; COMMUNICATION; SCALE; INDIVIDUALS; PREDICTIONMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60464

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