Horn, A., Krist, L., Lieb, W., Montellano, F. A., Kohls, M., Haas, K., Gelbrich, G., Bolay-Gehrig, S. J., Morbach, C., Reese, J. P., Stoerk, S., Fricke, J., Zoller, T., Schmidt, S., Triller, P., Kretzler, L., Roennefarth, M., Von Kalle, C., Willich, S. N., Kurth, F., Steinbeis, F., Witzenrath, M., Bahmer, T., Hermes, A., Krawczak, M., Reinke, L., Maetzler, C., Franzenburg, J., Enderle, J., Flinspach, A., Vehreschild, J., Schons, M., Illig, T., Anton, G., Ungethuem, K., Finkenberg, B. C., Gehrig, M. T., Savaskan, N., Heuschmann, P. U., Keil, T. and Schreiber, S. (2021). Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP). Infection, 49 (6). S. 1277 - 1288. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Purpose Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with non-hospitalized samples are rare. We, therefore, aimed to systematically assess the long-term health status of samples of hospitalized and non-hospitalized SARS-CoV-2 infected individuals from three regions in Germany. Methods The present paper describes the COVIDOM-study within the population-based cohort platform (POP) which has been established under the auspices of the NAPKON infrastructure (German National Pandemic Cohort Network) of the national Network University Medicine (NUM). Comprehensive health assessments among SARS-CoV-2 infected individuals are conducted at least 6 months after the acute infection at the study sites Kiel, Wurzburg and Berlin. Potential participants were identified and contacted via the local public health authorities, irrespective of the severity of the initial infection. A harmonized examination protocol has been implemented, consisting of detailed assessments of medical history, physical examinations, and the collection of multiple biosamples (e.g., serum, plasma, saliva, urine) for future analyses. In addition, patient-reported perception of the impact of local pandemic-related measures and infection on quality-of-life are obtained. Results As of July 2021, in total 6813 individuals infected in 2020 have been invited into the COVIDOM-study. Of these, about 36% wished to participate and 1295 have already been examined at least once. Conclusion NAPKON-POP COVIDOM-study complements other Long COVID studies assessing the long-term consequences of an infection with SARS-CoV-2 by providing detailed health data of population-based samples, including individuals with various degrees of disease severity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Horn, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krist, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lieb, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montellano, F. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohls, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gelbrich, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolay-Gehrig, S. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morbach, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reese, J. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoerk, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fricke, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zoller, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Triller, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretzler, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roennefarth, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Von Kalle, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willich, S. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurth, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinbeis, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witzenrath, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bahmer, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermes, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krawczak, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinke, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maetzler, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franzenburg, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enderle, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flinspach, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schons, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illig, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ungethuem, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finkenberg, B. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gehrig, M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Savaskan, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuschmann, P. U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keil, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604667
DOI: 10.1007/s15010-021-01707-5
Journal or Publication Title: Infection
Volume: 49
Number: 6
Page Range: S. 1277 - 1288
Date: 2021
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-0973
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LATE BREAKING ABSTRACTMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60466

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