Universität zu Köln

Berzow, Dirk, Descamps, Diane, Obermeier, Martin, Charpentier, Charlotte, Kaiser, Rolf, Guertler, Lutz, Eberle, Josef, Wensing, Annemarie, Sierra, Saleta, Ruelle, Jean, Gomes, Perpetua ORCID: 0000-0003-3271-8255, Mansinho, Kamal, Taylor, Ninon, Jensen, Bjorn, Doring, Matthias, Sturmer, Martin ORCID: 0000-0003-4300-9315, Rockstroh, Jurgen and Camacho, Ricardo (2021). Human Immunodeficiency Virus-2 (HIV-2): A Summary of the Present Standard of Care and Treatment Options for Individuals Living with HIV-2 in Western Europe. Clin. Infect. Dis., 72 (3). S. 503 - 510. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living with HIV-2 in Europe. Compared to HIV-1, there are differential characteristics of HIV-2 regarding diagnostic procedures, the clinical course, and, most importantly, antiretroviral therapy. We integrated the published literature on HIV-2 (studies and reports on epidemiology, diagnostics, the clinical course, and treatment), as well as expert experience in diagnosing and clinical care, to provide recommendations for a present standard of medical care of those living with HIV-2 in Western European countries, including an overview of strategies for diagnosis, monitoring, and treatment, with suggestions for effective drug combinations for first- and second-line treatments, post-exposure prophylaxis, and the prevention of mother-to-child transmission, as well as listings of mutations related to HIV-2 drug resistance and C-C motif chemokine receptor type 5 and C-X-C motif chemokine receptor type 4 coreceptor tropism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Berzow, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Descamps, Diane UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermeier, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Charpentier, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Guertler, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberle, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Wensing, Annemarie UNSPECIFIED UNSPECIFIED UNSPECIFIED Sierra, Saleta UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruelle, Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomes, Perpetua UNSPECIFIED orcid.org/0000-0003-3271-8255 UNSPECIFIED Mansinho, Kamal UNSPECIFIED UNSPECIFIED UNSPECIFIED Taylor, Ninon UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, Bjorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Doring, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturmer, Martin UNSPECIFIED orcid.org/0000-0003-4300-9315 UNSPECIFIED Rockstroh, Jurgen UNSPECIFIED UNSPECIFIED UNSPECIFIED Camacho, Ricardo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605525
DOI:	10.1093/cid/ciaa275
Journal or Publication Title:	Clin. Infect. Dis.
Volume:	72
Number:	3
Page Range:	S. 503 - 510
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1537-6591
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRUG-RESISTANCE; HIV-2-INFECTED PATIENTS; CELL COUNT; PCR ASSAY; INFECTION; DOLUTEGRAVIR; ASSOCIATION; INHIBITORS; SURVIVAL; COHORT Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60552