Ferini-Strambi, Luigi, Auer, Reto, Bjorvatn, Bjorn, Castronovo, Vincenza, Franco, Oscar, Gabutti, Luca, Galbiati, Andrea ORCID: 0000-0001-8132-1399, Hajak, Goeran, Khatami, Ramin, Kitajima, Tsuyoshi ORCID: 0000-0002-8785-9330, McEvoy, Doug, Nissen, Christoph, Perlis, Michael, Pevernagie, Dirk A., Randerath, Winfried, Riemann, Dieter, Rizzo, Giovanni, Van Someren, Eus, Vgontzas, Alexandros, Barazzoni, Fabrizio and Bassetti, Claudio (2021). Insomnia disorder: clinical and research challenges for the 21st century. Eur. J. Neurol., 28 (7). S. 2156 - 2168. HOBOKEN: WILEY. ISSN 1468-1331

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Abstract

Background and purpose Insomnia is a common and debilitating disorder that is frequently associated with important consequences for physical health and well-being. Methods An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field of insomnia and identified future priorities. Results The association of trajectories of insomnia with subsequent quality of life, health and mortality should be investigated in large populations. Prospective health economics studies by separating the costs driven specifically by insomnia and costs attributable to its long-term effects are needed. Ignoring the heterogeneity of insomnia patients leads to inadequate diagnosis and inefficient treatment. Individualized interventions should be promoted. More data are needed on both the impact of sleep on overnight effects, such as emotion regulation, and the potential compensatory effort to counteract diurnal impairments. Another gap is the definition of neurocognitive deficits in insomnia patients compared to normal subjects after chronic sleep loss. There are also a number of key gaps related to insomnia treatment. Expert guidelines indicate cognitive-behavioural therapy for insomnia as first-line treatment. They neglect, however, the reality of major healthcare providers. The role of combined therapy, cognitive-behavioural therapy for insomnia plus pharmacological treatment, should be evaluated more extensively. Conclusion Whilst insomnia disorder might affect large proportions of the population, there are a number of significant gaps in the epidemiological/clinical/research studies carried out to date. In particular, the identification of different insomnia phenotypes could allow more cost-effective and efficient therapies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ferini-Strambi, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auer, RetoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjorvatn, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castronovo, VincenzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franco, OscarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabutti, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galbiati, AndreaUNSPECIFIEDorcid.org/0000-0001-8132-1399UNSPECIFIED
Hajak, GoeranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khatami, RaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kitajima, TsuyoshiUNSPECIFIEDorcid.org/0000-0002-8785-9330UNSPECIFIED
McEvoy, DougUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nissen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perlis, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pevernagie, Dirk A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randerath, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemann, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizzo, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Someren, EusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vgontzas, AlexandrosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barazzoni, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bassetti, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605658
DOI: 10.1111/ene.14784
Journal or Publication Title: Eur. J. Neurol.
Volume: 28
Number: 7
Page Range: S. 2156 - 2168
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1331
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60565

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