Goldbrunner, Roland, Stavrinou, Pantelis, Jenkinson, Michael D., Sahm, Felix ORCID: 0000-0001-5441-1962, Mawrin, Christian, Weber, Damien C., Preusser, Matthias, Minniti, Giuseppe, Lund-Johansen, Morten, Lefranc, Florence, Houdart, Emanuel, Sallabanda, Kita, Le Rhun, Emilie, Nieuwenhuizen, David, Tabatabai, Ghazaleh, Soffietti, Riccardo ORCID: 0000-0002-9204-7038 and Weller, Michael (2021). EANO guideline on the diagnosis and management of meningiomas. Neuro-Oncology, 23 (11). S. 1821 - 1835. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials have been conducted to guide clinical decision making, resulting in variations of management approaches across countries and centers. However, recent advances in molecular genetics and clinical trial results help to refine the diagnostic and therapeutic approach to meningioma. Accordingly, the European Association of Neuro-Oncology (EANO) updated its recommendations for the diagnosis and treatment of meningiomas. A provisional diagnosis of meningioma is typically made by neuroimaging, mostly magnetic resonance imaging. Such provisional diagnoses may be made incidentally. Accordingly, a significant proportion of meningiomas, notably in patients that are asymptomatic or elderly or both, may be managed by a watch-and-scan strategy. A surgical intervention with tissue, commonly with the goal of gross total resection, is required for the definitive diagnosis according to the WHO classification. A role for molecular profiling including gene panel sequencing and genomic methylation profiling is emerging. A gross total surgical resection including the involved dura is often curative. Inoperable or recurrent tumors requiring treatment can be treated with radiosurgery, if the size or the vicinity of critical structures allows that, or with fractionated radiotherapy (RT). Treatment concepts combining surgery and radiosurgery or fractionated RT are increasingly used, although there remain controversies regard timing, type, and dosing of the various RT approaches. Radionuclide therapy targeting somatostatin receptors is an experimental approach, as are all approaches of systemic pharmacotherapy. The best albeit modest results with pharmacotherapy have been obtained with bevacizumab or multikinase inhibitors targeting vascular endothelial growth factor receptor, but no standard of care systemic treatment has been yet defined.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Goldbrunner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stavrinou, PantelisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkinson, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sahm, FelixUNSPECIFIEDorcid.org/0000-0001-5441-1962UNSPECIFIED
Mawrin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Damien C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preusser, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minniti, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lund-Johansen, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lefranc, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houdart, EmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sallabanda, KitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Rhun, EmilieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nieuwenhuizen, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabatabai, GhazalehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soffietti, RiccardoUNSPECIFIEDorcid.org/0000-0002-9204-7038UNSPECIFIED
Weller, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605803
DOI: 10.1093/neuonc/noab150
Journal or Publication Title: Neuro-Oncology
Volume: 23
Number: 11
Page Range: S. 1821 - 1835
Date: 2021
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1523-5866
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; CENTRAL-NERVOUS-SYSTEM; STEREOTACTIC RADIOSURGERY; INTRACRANIAL MENINGIOMAS; RADIONUCLIDE THERAPY; BRAIN INVASION; CELL-LINE; SURGERY; RADIOTHERAPY; MUTATIONSMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60580

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