Universität zu Köln

Marchant, Natalie L., Barnhofer, Thorsten, Coueron, Roxane, Wirth, Miranka, Lutz, Antoine, Arenaza-Urquijo, Eider M., Collette, Fabienne, Poisnel, Geraldine, Demnitz-King, Harriet, Schild, Ann-Katrin, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Delphin-Combe, Floriane, Whitfield, Tim, Schlosser, Marco ORCID: 0000-0002-0634-0749, Gonneaud, Julie ORCID: 0000-0003-0566-5581, Asselineau, Julien, Walker, Zuzana, Krolak-Salmon, Pierre, Molinuevo, Jose Luis, Frison, Eric ORCID: 0000-0001-5844-1886, Chetelat, Gael, Jessen, Frank and Klimecki, Olga M. (2021). Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial. Psychother. Psychosom., 90 (5). S. 341 - 351. BASEL: KARGER. ISSN 1423-0348

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Abstract

Introduction: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. Objective: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. Methods: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Participants were recruited from memory clinics at 4 European sites. The primary outcome was change in anxiety symptoms (trait subscale of the State-Trait Anxiety Inventory; trait-STAI) from pre- to postintervention. Secondary outcomes included a change in state anxiety and depression symptoms postintervention and 6 months postrandomization (follow-up). Results: One hundred forty-seven participants (mean [SD] age: 72.7 [6.9] years; 64.6% women; CMBAS, n = 73; HSMP, n = 74) were included in the intention-to-treat analysis. There was no difference in trait-STAI between groups postintervention (adjusted change difference: -1.25 points; 95% CI -4.76 to 2.25) or at follow-up (adjusted change difference: -0.43 points; 95% CI -2.92 to 2.07). Trait-STAI decreased postintervention in both groups (CMBAS: -3.43 points; 95% CI -5.27 to -1.59; HSMP: -2.29 points; 95% CI -4.14 to -0.44) and reductions were maintained at follow-up. No between-group differences were observed for change in state anxiety or depression symptoms. Conclusions: A time-limited mindfulness intervention is not superior to health self-management in reducing subclinical anxiety symptoms in SCD. The sustained reduction observed across both groups suggests that subclinical anxiety symptoms in SCD are modifiable. ClinicalTrials.gov identifier: NCT03005652.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marchant, Natalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnhofer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Coueron, Roxane UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Miranka UNSPECIFIED UNSPECIFIED UNSPECIFIED Lutz, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Arenaza-Urquijo, Eider M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Collette, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Poisnel, Geraldine UNSPECIFIED UNSPECIFIED UNSPECIFIED Demnitz-King, Harriet UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ann-Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Coll-Padros, Nina UNSPECIFIED orcid.org/0000-0002-9282-6701 UNSPECIFIED Delphin-Combe, Floriane UNSPECIFIED UNSPECIFIED UNSPECIFIED Whitfield, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlosser, Marco UNSPECIFIED orcid.org/0000-0002-0634-0749 UNSPECIFIED Gonneaud, Julie UNSPECIFIED orcid.org/0000-0003-0566-5581 UNSPECIFIED Asselineau, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Walker, Zuzana UNSPECIFIED UNSPECIFIED UNSPECIFIED Krolak-Salmon, Pierre UNSPECIFIED UNSPECIFIED UNSPECIFIED Molinuevo, Jose Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED Frison, Eric UNSPECIFIED orcid.org/0000-0001-5844-1886 UNSPECIFIED Chetelat, Gael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimecki, Olga M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-606558
DOI:	10.1159/000515669
Journal or Publication Title:	Psychother. Psychosom.
Volume:	90
Number:	5
Page Range:	S. 341 - 351
Date:	2021
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0348
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; TRAIT ANXIETY; STRESS REDUCTION; THERAPY; METAANALYSIS; SYMPTOMS; DEMENTIA; CRITERIA; RISK Multiple languages Psychiatry; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60655