Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Jamin, Christophe ORCID: 0000-0002-9494-3223, Barturen, Guillermo ORCID: 0000-0003-2103-1028, Desachy, Guillaume, Devauchelle-Pensec, Valerie, Boudjeniba, Cheiema, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodriguez-Pinto, Ignasi, De Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovacs, Laszlo, Witte, Torsten, Bettacchioli, Eleonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Orietta Borghi, Maria, Martin, Javier ORCID: 0000-0002-2202-0622, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickael, Moingeon, Philippe, Alarcon-Riquelme, Marta E., Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Saraux, Alain, Devauchelle-Pensec, Valerie, Cornec, Divi, Lauwerys, Bernard, Ducreux, Julie, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Neves, Esmeralda ORCID: 0000-0002-7754-8109, Faria, Raquel, Brandao, Mariana, Campar, Ana, Marinho, Antonio, Farinha, Fatima, Almeida, Isabel, Gonzalez-Gay Mantecon, Miguel Angel, Alonso, Ricardo Blanco, Martinez, Alfonso Corrales, Cervera, Ricard, Espinosa, Gerard ORCID: 0000-0003-1336-0163, Lories, Rik ORCID: 0000-0002-5986-3092, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Angeles Aguirre-Zamorano, Ma, Carmen Castro-Villegas, Ma, Jimenez Gomez, Yolanda, Ortego, Norberto, Fernandez Roldan, Maria Concepcion, Raya, Enrique, Moleon, Inmaculada Jimenez, de Ramon, Enrique, Quintero, Isabel Diaz, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Dulic, Sonja, Kadar, Gabriella, Hiepe, Falk, Gerl, Velia, Thiel, Silvia, Maresca, Manuel Rodriguez, Lopez-Berrio, Antonio, Aguilar-Quesada, Rocio, Navarro-Linares, Hector, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcon Riquelme, Marta, Gomes Anjos, Tania, Maranon, Concepcion ORCID: 0000-0002-7827-6301, Le Lann, Lucas, Simon, Quentin ORCID: 0000-0002-2383-2809, Rouviere, Benedicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Ger, Velia, Khodadadi, Laleh, Cheng, Qingyu, De Groof, Aurelie, Trombetta, Elena ORCID: 0000-0002-1933-6415, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Rao, Sambasiva and Jouve, Pierre-Emmanuel (2021). A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome. Nat. Commun., 12 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

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Abstract

There is currently no approved treatment for primary Sjogren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Here, we report, in a cross-sectional cohort, a molecular classification scheme for Sjogren's syndrome patients based on the multi-omic profiling of whole blood samples from a European cohort of over 300 patients, and a similar number of age and gender-matched healthy volunteers. Using transcriptomic, genomic, epigenetic, cytokine expression and flow cytometry data, combined with clinical parameters, we identify four groups of patients with distinct patterns of immune dysregulation. The biomarkers we identify can be used by machine learning classifiers to sort future patients into subgroups, allowing the re-evaluation of response to treatments in clinical trials. Sjogren's syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understanding of the disease and facilitate drug development.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Soret, PerrineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Dantec, ChristelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Desvaux, EmikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foulquier, NathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chassagnol, BastienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hubert, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamin, ChristopheUNSPECIFIEDorcid.org/0000-0002-9494-3223UNSPECIFIED
Barturen, GuillermoUNSPECIFIEDorcid.org/0000-0003-2103-1028UNSPECIFIED
Desachy, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devauchelle-Pensec, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boudjeniba, CheiemaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornec, DiviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saraux, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jousse-Joulin, SandrineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbarroja, NuriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Pinto, IgnasiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Langhe, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beretta, LorenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chizzolini, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovacs, LaszloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witte, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bettacchioli, EleonoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buttgereit, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makowska, ZuzannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lesche, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orietta Borghi, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, JavierUNSPECIFIEDorcid.org/0000-0002-2202-0622UNSPECIFIED
Courtade-Gaiani, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xuereb, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guedj, MickaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moingeon, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alarcon-Riquelme, Marta E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laigle, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pers, Jacques-OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vigone, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saraux, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devauchelle-Pensec, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornec, DiviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lauwerys, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ducreux, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maudoux, Anne-LiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasconcelos, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tavares, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neves, EsmeraldaUNSPECIFIEDorcid.org/0000-0002-7754-8109UNSPECIFIED
Faria, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandao, MarianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campar, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marinho, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farinha, FatimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Almeida, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Gay Mantecon, Miguel AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alonso, Ricardo BlancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez, Alfonso CorralesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cervera, RicardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinosa, GerardUNSPECIFIEDorcid.org/0000-0003-1336-0163UNSPECIFIED
Lories, RikUNSPECIFIEDorcid.org/0000-0002-5986-3092UNSPECIFIED
Hunzelmann, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belz, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baerlecken, NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stummvoll, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zauner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehner, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collantes, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortega-Castro, RafaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angeles Aguirre-Zamorano, MaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carmen Castro-Villegas, MaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez Gomez, YolandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortego, NorbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez Roldan, Maria ConcepcionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raya, EnriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moleon, Inmaculada JimenezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Ramon, EnriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quintero, Isabel DiazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meroni, Pier LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerosa, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schioppo, TommasoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Artusi, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dulic, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kadar, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hiepe, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerl, VeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiel, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maresca, Manuel RodriguezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Berrio, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aguilar-Quesada, RocioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navarro-Linares, HectorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ioannou, YiannisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chamberlain, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marovac, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alarcon Riquelme, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes Anjos, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maranon, ConcepcionUNSPECIFIEDorcid.org/0000-0002-7827-6301UNSPECIFIED
Le Lann, LucasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, QuentinUNSPECIFIEDorcid.org/0000-0002-2383-2809UNSPECIFIED
Rouviere, BenedicteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varela, NievesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muchmore, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dufour, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremer, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Pedrera, CharyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ger, VeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khodadadi, LalehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheng, QingyuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Groof, AurelieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trombetta, ElenaUNSPECIFIEDorcid.org/0000-0002-1933-6415UNSPECIFIED
Li, TianluUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez-Errico, DamianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kniesch, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azevedo, NancyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rao, SambasivaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jouve, Pierre-EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607129
DOI: 10.1038/s41467-021-23472-7
Journal or Publication Title: Nat. Commun.
Volume: 12
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL PHENOTYPES; INTERFERON; SIGNATURES; DISEASE; HYDROXYCHLOROQUINE; ASSOCIATION; MECHANISMS; RITUXIMAB; RESPONSES; EFFICACYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60712

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