Kitko, Carrie L., Pidala, Joseph, Schoemans, Helene M., Lawitschka, Anita, Flowers, Mary E., Cowen, Edward W., Tkaczyk, Eric ORCID: 0000-0002-2850-4740, Farhadfar, Nosha, Jain, Sandeep, Steven, Philipp, Luo, Zhonghui K., Ogawa, Yoko ORCID: 0000-0002-2906-9621, Stern, Michael, Yanik, Greg A., Cuvelier, Geoffrey D. E., Cheng, Guang-Shing, Holtan, Shernan G., Schultz, Kirk R., Martin, Paul J., Lee, Stephanie J., Pavletic, Steven Z., Wolff, Daniel, Paczesny, Sophie, Blazar, Bruce R., Sarantopoulos, Stephanie, Socie, Gerard, Greinix, Hildegard and Cutler, Corey (2021). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transpl. Cell. Ther., 27 (7). S. 545 - 558. NEW YORK: ELSEVIER SCIENCE INC. ISSN 2666-6367

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Abstract

Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by the National Institutes of Health (NIH) 2005 and 2014 consensus projects has helped improve diagnostic accuracy and severity scoring for clinical trials, but utilization of these tools in routine clinical practice is variable. Additionally, when patients meet the NIH diagnostic criteria, many already have significant morbidity and possibly irreversible organ damage. The goals of this early diagnosis project are 2-fold. First, we provide consensus recommendations regarding implementation of the current NIH diagnostic guidelines into routine transplant care, outside of clinical trials, aiming to enhance early clinical recognition of chronic GVHD. Second, we propose directions for future research efforts to enable discovery of new, early laboratory as well as clinical indicators of chronic GVHD, both globally and for highly morbid organ-specific manifestations. Identification of early features of chronic GVHD that have high positive predictive value for progression to more severe manifestations of the disease could potentially allow for future pre-emptive clinical trials. (C) 2021 The American Society for Transplantation and Cellular Therapy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kitko, Carrie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pidala, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoemans, Helene M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawitschka, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flowers, Mary E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cowen, Edward W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tkaczyk, EricUNSPECIFIEDorcid.org/0000-0002-2850-4740UNSPECIFIED
Farhadfar, NoshaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jain, SandeepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steven, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luo, Zhonghui K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ogawa, YokoUNSPECIFIEDorcid.org/0000-0002-2906-9621UNSPECIFIED
Stern, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yanik, Greg A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuvelier, Geoffrey D. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheng, Guang-ShingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtan, Shernan G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultz, Kirk R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, Paul J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Stephanie J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavletic, Steven Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolff, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paczesny, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blazar, Bruce R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarantopoulos, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Socie, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greinix, HildegardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cutler, CoreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607333
DOI: 10.1016/j.jtct.2021.03.033
Journal or Publication Title: Transpl. Cell. Ther.
Volume: 27
Number: 7
Page Range: S. 545 - 558
Date: 2021
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 2666-6367
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BRONCHIOLITIS-OBLITERANS-SYNDROME; HEMATOPOIETIC-CELL TRANSPLANTATION; MEASURING THERAPEUTIC RESPONSE; FORCED EXPIRATORY FLOW; DRY EYE; PROGNOSTIC VALUE; PREDICTIVE-VALUE; CHRONIC GVHD; RISK-FACTORS; LUNGMultiple languages
Hematology; Immunology; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60733

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