Medina, Narda ORCID: 0000-0001-6176-0052, Soto-Debran, Juan Carlos, Seidel, Danila, Akyar, Isin, Badali, Hamid ORCID: 0000-0002-6010-8414, Barac, Aleksandra ORCID: 0000-0002-0132-2277, Bretagne, Stephane ORCID: 0000-0001-6870-3800, Cag, Yasemin, Cassagne, Carole, Castro, Carmen, Chakrabarti, Arunaloke ORCID: 0000-0003-1555-3807, Dannaoui, Eric, Cardozo, Celia, Garcia-Rodriguez, Julio ORCID: 0000-0002-3771-8740, Guitard, Juliette ORCID: 0000-0002-9782-3577, Hamal, Petr ORCID: 0000-0002-5361-8125, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Jagielski, Tomasz ORCID: 0000-0001-9553-5742, Khodavaisy, Sadegh ORCID: 0000-0001-8039-4991, Lo Cascio, Giuliana, Martinez-Rubio, Maria Carmen, Meletiadis, Joseph ORCID: 0000-0002-8869-1509, Munoz, Patricia, Ochman, Elzbieta, Pelaez, Teresa, Perez-Ayala Balzola, Ana, Prattes, Juergen ORCID: 0000-0001-5751-9311, Roilides, Emmanuel ORCID: 0000-0002-0202-364X, Ruiz-Perez de Pipaon, Maite, Stauf, Raphael, Steinmann, Joerg, Suarez-Barrenechea, Ana Isabel, Tejero, Rocio, Trovato, Laura, Vinuela, Lourdes ORCID: 0000-0002-9990-9657, Wongsuk, Thanwa, Zak, Iwona, Zarrinfar, Hossein ORCID: 0000-0002-1449-4668, Lass-Florl, Cornelia ORCID: 0000-0002-2946-7785, Arikan-Akdagli, Sevtap ORCID: 0000-0001-9807-6764 and Alastruey-Izquierdo, Ana ORCID: 0000-0001-8651-4405 (2021). MixInYeast: A Multicenter Study on Mixed Yeast Infections. J. Fungi, 7 (1). BASEL: MDPI. ISSN 2309-608X

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Abstract

Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Medina, NardaUNSPECIFIEDorcid.org/0000-0001-6176-0052UNSPECIFIED
Soto-Debran, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akyar, IsinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Badali, HamidUNSPECIFIEDorcid.org/0000-0002-6010-8414UNSPECIFIED
Barac, AleksandraUNSPECIFIEDorcid.org/0000-0002-0132-2277UNSPECIFIED
Bretagne, StephaneUNSPECIFIEDorcid.org/0000-0001-6870-3800UNSPECIFIED
Cag, YaseminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cassagne, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castro, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakrabarti, ArunalokeUNSPECIFIEDorcid.org/0000-0003-1555-3807UNSPECIFIED
Dannaoui, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardozo, CeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Rodriguez, JulioUNSPECIFIEDorcid.org/0000-0002-3771-8740UNSPECIFIED
Guitard, JulietteUNSPECIFIEDorcid.org/0000-0002-9782-3577UNSPECIFIED
Hamal, PetrUNSPECIFIEDorcid.org/0000-0002-5361-8125UNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Jagielski, TomaszUNSPECIFIEDorcid.org/0000-0001-9553-5742UNSPECIFIED
Khodavaisy, SadeghUNSPECIFIEDorcid.org/0000-0001-8039-4991UNSPECIFIED
Lo Cascio, GiulianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Rubio, Maria CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meletiadis, JosephUNSPECIFIEDorcid.org/0000-0002-8869-1509UNSPECIFIED
Munoz, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ochman, ElzbietaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelaez, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Ayala Balzola, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prattes, JuergenUNSPECIFIEDorcid.org/0000-0001-5751-9311UNSPECIFIED
Roilides, EmmanuelUNSPECIFIEDorcid.org/0000-0002-0202-364XUNSPECIFIED
Ruiz-Perez de Pipaon, MaiteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stauf, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinmann, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suarez-Barrenechea, Ana IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tejero, RocioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trovato, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vinuela, LourdesUNSPECIFIEDorcid.org/0000-0002-9990-9657UNSPECIFIED
Wongsuk, ThanwaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zak, IwonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zarrinfar, HosseinUNSPECIFIEDorcid.org/0000-0002-1449-4668UNSPECIFIED
Lass-Florl, CorneliaUNSPECIFIEDorcid.org/0000-0002-2946-7785UNSPECIFIED
Arikan-Akdagli, SevtapUNSPECIFIEDorcid.org/0000-0001-9807-6764UNSPECIFIED
Alastruey-Izquierdo, AnaUNSPECIFIEDorcid.org/0000-0001-8651-4405UNSPECIFIED
URN: urn:nbn:de:hbz:38-607963
DOI: 10.3390/jof7010013
Journal or Publication Title: J. Fungi
Volume: 7
Number: 1
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2309-608X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Microbiology; MycologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60796

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