de Rojas, Itziar
ORCID: 0000-0002-2148-381X, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernandez, Isabel, Montrreal, Laura, Antunez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Celine, Quintela, Ines
ORCID: 0000-0002-0239-7975, Gonzalez-Perez, Antonio, Calero, Miguel
ORCID: 0000-0001-5366-3324, Franco-Macias, Emilio, Macias, Juan
ORCID: 0000-0002-4778-790X, Blesa, Rafael, Cervera-Carles, Laura
ORCID: 0000-0003-2286-200X, Menendez-Gonzalez, Manuel, Frank-Garcia, Ana, Luis Royo, Jose, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Monica, Lage, Carmen, Garcia-Madrona, Sebastian, Garcia-Gonzalez, Pablo, Alarcon-Martin, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar
ORCID: 0000-0002-9679-0670, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Perez-Cordon, Alba, Benussi, Alberto
ORCID: 0000-0002-8703-6940, Rabano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonca, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Belen Pastor, Ana, Espinosa, Ana, Corma-Gomez, Anais, Martin Montes, Angel, Sanabria, Angela, DeStefano, Anita L., Schneider, Anja
ORCID: 0000-0001-9540-8700, Haapasalo, Annakaisa, Stahlbom, Anne Kinhult, Tybjaerg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbaton-Anchuelo, Arturo
ORCID: 0000-0002-8775-4766, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta
ORCID: 0000-0001-9338-9040, Nordestgaard, Borge G., Kunkle, Brian W., Charbonnier, Camille
ORCID: 0000-0003-1172-0196, Abdelnour, Carla, Masullo, Carlo, Martinez Rodriguez, Carmen, Munoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher
ORCID: 0000-0001-7210-7702, Pisanu, Claudia
ORCID: 0000-0002-9151-4319, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag
ORCID: 0000-0001-6314-216X, Rujescu, Dan, Alcolea, Daniel
ORCID: 0000-0002-3819-3245, Galimberti, Daniela
ORCID: 0000-0002-9284-5953, Wallon, David, Seripa, Davide
ORCID: 0000-0001-7331-0470, Gruenblatt, Edna, Dardiotis, Efthimios, Duezel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa
ORCID: 0000-0002-7553-7553, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy
ORCID: 0000-0001-7742-677X, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn
ORCID: 0000-0002-7423-3793, Tagliavini, Fabrizio, Kucukali, Fahri
ORCID: 0000-0002-3835-9639, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca
ORCID: 0000-0002-2686-3926, Jessen, Frank, Nicolas, Gael, Selbaek, Geir, Ortega, Gemma, Chene, Genevieve, Hadjigeorgiou, Georgios, Rossi, Giacomina
ORCID: 0000-0001-6680-2725, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald
ORCID: 0000-0003-0894-8982, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio
ORCID: 0000-0002-8537-3935, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild
ORCID: 0000-0002-7897-9808, Rainero, Innocenzo, Allende, Irene Rosas, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien
ORCID: 0000-0001-6770-0720, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist
ORCID: 0000-0003-3484-9531, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan
ORCID: 0000-0002-1340-638X, Popp, Julius
ORCID: 0000-0002-0068-0312, Deckert, Juergen, Buerger, Katharina, Morgan, Kevin, Fliessbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla
ORCID: 0000-0001-5722-3967, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa
ORCID: 0000-0003-2836-8141, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitee, Lowenmark, Malin, Hulsman, Marc, Spallazzi, Marco
ORCID: 0000-0002-8091-2063, Pericak-Vance, Margaret A., Esiri, Margaret, Sanchez-Arjona, Maria Bernal, Carolina Dalmasso, Maria, Teresa Martinez-Larrad, Maria, Arcaro, Marina, Noethen, Markus M., Fernandez-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary
ORCID: 0000-0003-2171-7337, Schmid, Matthias
ORCID: 0000-0002-0788-0317, Ewers, Michael, Heneka, Michael T., Wagner, Michael
ORCID: 0000-0003-2589-6440, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M.
ORCID: 0000-0002-8381-9657, Banaj, Nerisa
ORCID: 0000-0002-6317-8549, Armstrong, Nicola J., Scarmeas, Nikolaos
ORCID: 0000-0001-6453-8908, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossu, Paola, Caffarra, Paolo, Rossi, Paolo Dionigi, Sakka, Paraskevi, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik
ORCID: 0000-0001-6237-2502, Cecchetti, Roberta, Ghidoni, Roberta
ORCID: 0000-0002-7691-1957, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hagg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Sando, Sigrid Botne, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon
ORCID: 0000-0002-4326-1468, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina
ORCID: 0000-0002-6176-3584, Escott-Price, Valentina
ORCID: 0000-0003-1784-5483, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Smith, A. David, Abdelnour, C., Adarmes-Gomez, A. D., Macleod, C., Jansen, Iris E., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sanchez-Juan, Pascual, Pastor, Pau
ORCID: 0000-0002-7493-8777, Perez-Tur, Jordi, Pinol-Ripoll, Gerard, de Munain, Adolfo Lopez, Maria Garcia-Alberca, Jose, Bullido, Maria J., Alvarez, Victoria, Lleo, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquie, Marta, Eugenia Saez, Maria, Carracedo, Angel
ORCID: 0000-0003-1085-8986, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie
ORCID: 0000-0002-4069-0259, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sanchez-Valle, Raquel, Serrano-Rios, Manuel, Orellana, Adelina
ORCID: 0000-0002-0204-1944, Tarraga, Lluis, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle
ORCID: 0000-0001-7582-2365, Clarimon, Jordi, Boada, Merce, van der Flier, Wiesje M., Ramirez, Alfredo
ORCID: 0000-0003-4991-763X, Lambert, Jean-Charles, van der Lee, Sven J. and Ruiz, Agustin
(2021).
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
Nat. Commun., 12 (1).
BERLIN:
NATURE PORTFOLIO.
ISSN 2041-1723
Full text not available from this repository.
Abstract
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n=409,435 and validation size n=58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE 4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease. Known genetic loci account for only a fraction of the genetic contribution to Alzheimer's disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer's disease polygenic risk score.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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de Rojas, Itziar | UNSPECIFIED | orcid.org/0000-0002-2148-381X | UNSPECIFIED | Moreno-Grau, Sonia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tesi, Niccolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grenier-Boley, Benjamin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Andrade, Victor | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jansen, Iris E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pedersen, Nancy L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stringa, Najada | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zettergren, Anna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hernandez, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Montrreal, Laura | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Antunez, Carmen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Antonell, Anna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tankard, Rick M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bis, Joshua C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sims, Rebecca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bellenguez, Celine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Quintela, Ines | UNSPECIFIED | orcid.org/0000-0002-0239-7975 | UNSPECIFIED | Gonzalez-Perez, Antonio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Calero, Miguel | UNSPECIFIED | orcid.org/0000-0001-5366-3324 | UNSPECIFIED | Franco-Macias, Emilio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Macias, Juan | UNSPECIFIED | orcid.org/0000-0002-4778-790X | UNSPECIFIED | Blesa, Rafael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cervera-Carles, Laura | UNSPECIFIED | orcid.org/0000-0003-2286-200X | UNSPECIFIED | Menendez-Gonzalez, Manuel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Frank-Garcia, Ana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Luis Royo, Jose | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moreno, Fermin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Huerto Vilas, Raquel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baquero, Miquel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Diez-Fairen, Monica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lage, Carmen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garcia-Madrona, Sebastian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garcia-Gonzalez, Pablo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Alarcon-Martin, Emilio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Valero, Sergi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sotolongo-Grau, Oscar | UNSPECIFIED | orcid.org/0000-0002-9679-0670 | UNSPECIFIED | Ullgren, Abbe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Naj, Adam C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lemstra, Afina W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benaque, Alba | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Perez-Cordon, Alba | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benussi, Alberto | UNSPECIFIED | orcid.org/0000-0002-8703-6940 | UNSPECIFIED | Rabano, Alberto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Padovani, Alessandro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Squassina, Alessio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Mendonca, Alexandre | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arias Pastor, Alfonso | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kok, Almar A. L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meggy, Alun | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Belen Pastor, Ana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Espinosa, Ana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Corma-Gomez, Anais | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martin Montes, Angel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sanabria, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | DeStefano, Anita L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schneider, Anja | UNSPECIFIED | orcid.org/0000-0001-9540-8700 | UNSPECIFIED | Haapasalo, Annakaisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stahlbom, Anne Kinhult | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tybjaerg-Hansen, Anne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hartmann, Annette M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Spottke, Annika | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Corbaton-Anchuelo, Arturo | UNSPECIFIED | orcid.org/0000-0002-8775-4766 | UNSPECIFIED | Rongve, Arvid | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Borroni, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arosio, Beatrice | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nacmias, Benedetta | UNSPECIFIED | orcid.org/0000-0001-9338-9040 | UNSPECIFIED | Nordestgaard, Borge G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kunkle, Brian W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Charbonnier, Camille | UNSPECIFIED | orcid.org/0000-0003-1172-0196 | UNSPECIFIED | Abdelnour, Carla | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Masullo, Carlo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martinez Rodriguez, Carmen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Munoz-Fernandez, Carmen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dufouil, Carole | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Graff, Caroline | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ferreira, Catarina B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chillotti, Caterina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reynolds, Chandra A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fenoglio, Chiara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Van Broeckhoven, Christine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Clark, Christopher | UNSPECIFIED | orcid.org/0000-0001-7210-7702 | UNSPECIFIED | Pisanu, Claudia | UNSPECIFIED | orcid.org/0000-0002-9151-4319 | UNSPECIFIED | Satizabal, Claudia L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Holmes, Clive | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buiza-Rueda, Dolores | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aarsland, Dag | UNSPECIFIED | orcid.org/0000-0001-6314-216X | UNSPECIFIED | Rujescu, Dan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Alcolea, Daniel | UNSPECIFIED | orcid.org/0000-0002-3819-3245 | UNSPECIFIED | Galimberti, Daniela | UNSPECIFIED | orcid.org/0000-0002-9284-5953 | UNSPECIFIED | Wallon, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seripa, Davide | UNSPECIFIED | orcid.org/0000-0001-7331-0470 | UNSPECIFIED | Gruenblatt, Edna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dardiotis, Efthimios | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Duezel, Emrah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scarpini, Elio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Conti, Elisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rubino, Elisa | UNSPECIFIED | orcid.org/0000-0002-7553-7553 | UNSPECIFIED | Gelpi, Ellen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rodriguez-Rodriguez, Eloy | UNSPECIFIED | orcid.org/0000-0001-7742-677X | UNSPECIFIED | Duron, Emmanuelle | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Boerwinkle, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ferri, Evelyn | UNSPECIFIED | orcid.org/0000-0002-7423-3793 | UNSPECIFIED | Tagliavini, Fabrizio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kucukali, Fahri | UNSPECIFIED | orcid.org/0000-0002-3835-9639 | UNSPECIFIED | Pasquier, Florence | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sanchez-Garcia, Florentino | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mangialasche, Francesca | UNSPECIFIED | orcid.org/0000-0002-2686-3926 | UNSPECIFIED | Jessen, Frank | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nicolas, Gael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Selbaek, Geir | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ortega, Gemma | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chene, Genevieve | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hadjigeorgiou, Georgios | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rossi, Giacomina | UNSPECIFIED | orcid.org/0000-0001-6680-2725 | UNSPECIFIED | Spalletta, Gianfranco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giaccone, Giorgio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grande, Giulia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Binetti, Giuliano | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Papenberg, Goran | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hampel, Harald | UNSPECIFIED | orcid.org/0000-0003-0894-8982 | UNSPECIFIED | Bailly, Henri | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zetterberg, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Soininen, Hilkka | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Karlsson, Ida K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Alvarez, Ignacio | UNSPECIFIED | orcid.org/0000-0002-8537-3935 | UNSPECIFIED | Appollonio, Ildebrando | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giegling, Ina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Skoog, Ingmar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saltvedt, Ingvild | UNSPECIFIED | orcid.org/0000-0002-7897-9808 | UNSPECIFIED | Rainero, Innocenzo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Allende, Irene Rosas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hort, Jakub | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Diehl-Schmid, Janine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Van Dongen, Jasper | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vidal, Jean-Sebastien | UNSPECIFIED | orcid.org/0000-0001-6770-0720 | UNSPECIFIED | Lehtisalo, Jenni | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wiltfang, Jens | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Thomassen, Jesper Qvist | UNSPECIFIED | orcid.org/0000-0003-3484-9531 | UNSPECIFIED | Kornhuber, Johannes | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Haines, Jonathan L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vogelgsang, Jonathan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pineda, Juan A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fortea, Juan | UNSPECIFIED | orcid.org/0000-0002-1340-638X | UNSPECIFIED | Popp, Julius | UNSPECIFIED | orcid.org/0000-0002-0068-0312 | UNSPECIFIED | Deckert, Juergen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buerger, Katharina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Morgan, Kevin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fliessbach, Klaus | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sleegers, Kristel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Molina-Porcel, Laura | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kilander, Lena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weinhold, Leonie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Farrer, Lindsay A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Li-San | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kleineidam, Luca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Farotti, Lucia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Parnetti, Lucilla | UNSPECIFIED | orcid.org/0000-0001-5722-3967 | UNSPECIFIED | Tremolizzo, Lucio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hausner, Lucrezia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benussi, Luisa | UNSPECIFIED | orcid.org/0000-0003-2836-8141 | UNSPECIFIED | Froelich, Lutz | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ikram, M. Arfan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Deniz-Naranjo, M. Candida | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tsolaki, Magda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rosende-Roca, Maitee | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lowenmark, Malin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hulsman, Marc | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Spallazzi, Marco | UNSPECIFIED | orcid.org/0000-0002-8091-2063 | UNSPECIFIED | Pericak-Vance, Margaret A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Esiri, Margaret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sanchez-Arjona, Maria Bernal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Carolina Dalmasso, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Teresa Martinez-Larrad, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arcaro, Marina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Noethen, Markus M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fernandez-Fuertes, Marta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dichgans, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ingelsson, Martin | 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|
URN: |
urn:nbn:de:hbz:38-608531 |
DOI: |
10.1038/s41467-021-22491-8 |
Journal or Publication Title: |
Nat. Commun. |
Volume: |
12 |
Number: |
1 |
Date: |
2021 |
Publisher: |
NATURE PORTFOLIO |
Place of Publication: |
BERLIN |
ISSN: |
2041-1723 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
SUSCEPTIBILITY LOCI; FAMILY-HISTORY; METAANALYSIS; IMMUNITY; AGE | Multiple languages | Multidisciplinary Sciences | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/60853 |
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