de Rojas, Itziar ORCID: 0000-0002-2148-381X, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernandez, Isabel, Montrreal, Laura, Antunez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Celine, Quintela, Ines ORCID: 0000-0002-0239-7975, Gonzalez-Perez, Antonio, Calero, Miguel ORCID: 0000-0001-5366-3324, Franco-Macias, Emilio, Macias, Juan ORCID: 0000-0002-4778-790X, Blesa, Rafael, Cervera-Carles, Laura ORCID: 0000-0003-2286-200X, Menendez-Gonzalez, Manuel, Frank-Garcia, Ana, Luis Royo, Jose, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Monica, Lage, Carmen, Garcia-Madrona, Sebastian, Garcia-Gonzalez, Pablo, Alarcon-Martin, Emilio, Valero, Sergi, Sotolongo-Grau, Oscar ORCID: 0000-0002-9679-0670, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benaque, Alba, Perez-Cordon, Alba, Benussi, Alberto ORCID: 0000-0002-8703-6940, Rabano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonca, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Belen Pastor, Ana, Espinosa, Ana, Corma-Gomez, Anais, Martin Montes, Angel, Sanabria, Angela, DeStefano, Anita L., Schneider, Anja ORCID: 0000-0001-9540-8700, Haapasalo, Annakaisa, Stahlbom, Anne Kinhult, Tybjaerg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbaton-Anchuelo, Arturo ORCID: 0000-0002-8775-4766, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta ORCID: 0000-0001-9338-9040, Nordestgaard, Borge G., Kunkle, Brian W., Charbonnier, Camille ORCID: 0000-0003-1172-0196, Abdelnour, Carla, Masullo, Carlo, Martinez Rodriguez, Carmen, Munoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher ORCID: 0000-0001-7210-7702, Pisanu, Claudia ORCID: 0000-0002-9151-4319, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag ORCID: 0000-0001-6314-216X, Rujescu, Dan, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Galimberti, Daniela ORCID: 0000-0002-9284-5953, Wallon, David, Seripa, Davide ORCID: 0000-0001-7331-0470, Gruenblatt, Edna, Dardiotis, Efthimios, Duezel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa ORCID: 0000-0002-7553-7553, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy ORCID: 0000-0001-7742-677X, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn ORCID: 0000-0002-7423-3793, Tagliavini, Fabrizio, Kucukali, Fahri ORCID: 0000-0002-3835-9639, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca ORCID: 0000-0002-2686-3926, Jessen, Frank, Nicolas, Gael, Selbaek, Geir, Ortega, Gemma, Chene, Genevieve, Hadjigeorgiou, Georgios, Rossi, Giacomina ORCID: 0000-0001-6680-2725, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald ORCID: 0000-0003-0894-8982, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio ORCID: 0000-0002-8537-3935, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild ORCID: 0000-0002-7897-9808, Rainero, Innocenzo, Allende, Irene Rosas, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien ORCID: 0000-0001-6770-0720, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist ORCID: 0000-0003-3484-9531, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan ORCID: 0000-0002-1340-638X, Popp, Julius ORCID: 0000-0002-0068-0312, Deckert, Juergen, Buerger, Katharina, Morgan, Kevin, Fliessbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla ORCID: 0000-0001-5722-3967, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa ORCID: 0000-0003-2836-8141, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitee, Lowenmark, Malin, Hulsman, Marc, Spallazzi, Marco ORCID: 0000-0002-8091-2063, Pericak-Vance, Margaret A., Esiri, Margaret, Sanchez-Arjona, Maria Bernal, Carolina Dalmasso, Maria, Teresa Martinez-Larrad, Maria, Arcaro, Marina, Noethen, Markus M., Fernandez-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary ORCID: 0000-0003-2171-7337, Schmid, Matthias ORCID: 0000-0002-0788-0317, Ewers, Michael, Heneka, Michael T., Wagner, Michael ORCID: 0000-0003-2589-6440, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M. ORCID: 0000-0002-8381-9657, Banaj, Nerisa ORCID: 0000-0002-6317-8549, Armstrong, Nicola J., Scarmeas, Nikolaos ORCID: 0000-0001-6453-8908, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossu, Paola, Caffarra, Paolo, Rossi, Paolo Dionigi, Sakka, Paraskevi, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik ORCID: 0000-0001-6237-2502, Cecchetti, Roberta, Ghidoni, Roberta ORCID: 0000-0002-7691-1957, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hagg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Sando, Sigrid Botne, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon ORCID: 0000-0002-4326-1468, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina ORCID: 0000-0002-6176-3584, Escott-Price, Valentina ORCID: 0000-0003-1784-5483, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Smith, A. David, Abdelnour, C., Adarmes-Gomez, A. D., Macleod, C., Jansen, Iris E., Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sanchez-Juan, Pascual, Pastor, Pau ORCID: 0000-0002-7493-8777, Perez-Tur, Jordi, Pinol-Ripoll, Gerard, de Munain, Adolfo Lopez, Maria Garcia-Alberca, Jose, Bullido, Maria J., Alvarez, Victoria, Lleo, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquie, Marta, Eugenia Saez, Maria, Carracedo, Angel ORCID: 0000-0003-1085-8986, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie ORCID: 0000-0002-4069-0259, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sanchez-Valle, Raquel, Serrano-Rios, Manuel, Orellana, Adelina ORCID: 0000-0002-0204-1944, Tarraga, Lluis, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle ORCID: 0000-0001-7582-2365, Clarimon, Jordi, Boada, Merce, van der Flier, Wiesje M., Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Lambert, Jean-Charles, van der Lee, Sven J. and Ruiz, Agustin (2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Full text not available from this repository.

Abstract

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n=409,435 and validation size n=58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE 4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease. Known genetic loci account for only a fraction of the genetic contribution to Alzheimer's disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer's disease polygenic risk score.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
de Rojas, ItziarUNSPECIFIEDorcid.org/0000-0002-2148-381XUNSPECIFIED
Moreno-Grau, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tesi, NiccoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grenier-Boley, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrade, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, Iris E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pedersen, Nancy L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stringa, NajadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zettergren, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hernandez, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montrreal, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antunez, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonell, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tankard, Rick M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bis, Joshua C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sims, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bellenguez, CelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quintela, InesUNSPECIFIEDorcid.org/0000-0002-0239-7975UNSPECIFIED
Gonzalez-Perez, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calero, MiguelUNSPECIFIEDorcid.org/0000-0001-5366-3324UNSPECIFIED
Franco-Macias, EmilioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macias, JuanUNSPECIFIEDorcid.org/0000-0002-4778-790XUNSPECIFIED
Blesa, RafaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cervera-Carles, LauraUNSPECIFIEDorcid.org/0000-0003-2286-200XUNSPECIFIED
Menendez-Gonzalez, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frank-Garcia, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luis Royo, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreno, FerminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huerto Vilas, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baquero, MiquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diez-Fairen, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lage, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Madrona, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Gonzalez, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alarcon-Martin, EmilioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valero, SergiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sotolongo-Grau, OscarUNSPECIFIEDorcid.org/0000-0002-9679-0670UNSPECIFIED
Ullgren, AbbeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naj, Adam C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemstra, Afina W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benaque, AlbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Cordon, AlbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benussi, AlbertoUNSPECIFIEDorcid.org/0000-0002-8703-6940UNSPECIFIED
Rabano, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Padovani, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Squassina, AlessioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Mendonca, AlexandreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arias Pastor, AlfonsoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kok, Almar A. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meggy, AlunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belen Pastor, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinosa, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corma-Gomez, AnaisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin Montes, AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanabria, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DeStefano, Anita L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Haapasalo, AnnakaisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stahlbom, Anne KinhultUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tybjaerg-Hansen, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, Annette M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corbaton-Anchuelo, ArturoUNSPECIFIEDorcid.org/0000-0002-8775-4766UNSPECIFIED
Rongve, ArvidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borroni, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arosio, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nacmias, BenedettaUNSPECIFIEDorcid.org/0000-0001-9338-9040UNSPECIFIED
Nordestgaard, Borge G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunkle, Brian W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Charbonnier, CamilleUNSPECIFIEDorcid.org/0000-0003-1172-0196UNSPECIFIED
Abdelnour, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masullo, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez Rodriguez, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munoz-Fernandez, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dufouil, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graff, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferreira, Catarina B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chillotti, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reynolds, Chandra A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fenoglio, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Broeckhoven, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clark, ChristopherUNSPECIFIEDorcid.org/0000-0001-7210-7702UNSPECIFIED
Pisanu, ClaudiaUNSPECIFIEDorcid.org/0000-0002-9151-4319UNSPECIFIED
Satizabal, Claudia L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmes, CliveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buiza-Rueda, DoloresUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aarsland, DagUNSPECIFIEDorcid.org/0000-0001-6314-216XUNSPECIFIED
Rujescu, DanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcolea, DanielUNSPECIFIEDorcid.org/0000-0002-3819-3245UNSPECIFIED
Galimberti, DanielaUNSPECIFIEDorcid.org/0000-0002-9284-5953UNSPECIFIED
Wallon, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seripa, DavideUNSPECIFIEDorcid.org/0000-0001-7331-0470UNSPECIFIED
Gruenblatt, EdnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dardiotis, EfthimiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scarpini, ElioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conti, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rubino, ElisaUNSPECIFIEDorcid.org/0000-0002-7553-7553UNSPECIFIED
Gelpi, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Duron, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boerwinkle, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferri, EvelynUNSPECIFIEDorcid.org/0000-0002-7423-3793UNSPECIFIED
Tagliavini, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kucukali, FahriUNSPECIFIEDorcid.org/0000-0002-3835-9639UNSPECIFIED
Pasquier, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Garcia, FlorentinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangialasche, FrancescaUNSPECIFIEDorcid.org/0000-0002-2686-3926UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nicolas, GaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Spalletta, GianfrancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giaccone, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grande, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Binetti, GiulianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papenberg, GoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDorcid.org/0000-0003-0894-8982UNSPECIFIED
Bailly, HenriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zetterberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soininen, HilkkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karlsson, Ida K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, IgnacioUNSPECIFIEDorcid.org/0000-0002-8537-3935UNSPECIFIED
Appollonio, IldebrandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Scherbaum, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Hanon, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skrobot, Olivia AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Lerch, OndrejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Caffarra, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, Paolo DionigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakka, ParaskeviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmans, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riederer, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, QiongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marshall, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalaria, Rajesh N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayeux, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandenberghe, RikUNSPECIFIEDorcid.org/0000-0001-6237-2502UNSPECIFIED
Cecchetti, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghidoni, RobertaUNSPECIFIEDorcid.org/0000-0002-7691-1957UNSPECIFIED
Frikke-Schmidt, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorbi, SandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagg, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelborghs, SebastiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helisalmi, SeppoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sando, Sigrid BotneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Archetti, SilvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boschi, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fostinelli, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gil, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendoza, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mead, SimonUNSPECIFIEDorcid.org/0000-0002-4326-1468UNSPECIFIED
Ciccone, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Djurovic, SrdjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heilmann-Heimbach, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, SteffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuulasmaa, TeemuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Ser, TeodoroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lebouvier, ThibaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polak, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ngandu, TiiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimmer, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bessi, ValentinaUNSPECIFIEDorcid.org/0000-0002-6176-3584UNSPECIFIED
Escott-Price, ValentinaUNSPECIFIEDorcid.org/0000-0003-1784-5483UNSPECIFIED
Giedraitis, VilmantasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deramecourt, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jian, XueqiuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pijnenburg, Yolande A. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, A. DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abdelnour, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adarmes-Gomez, A. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macleod, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, Iris E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kehoe, Patrick GavinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Ribas, GuillermoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Juan, PascualUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pastor, PauUNSPECIFIEDorcid.org/0000-0002-7493-8777UNSPECIFIED
Perez-Tur, JordiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinol-Ripoll, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Munain, Adolfo LopezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maria Garcia-Alberca, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bullido, Maria J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lleo, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Real, Luis M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mir, PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medina, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holstege, HenneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marquie, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eugenia Saez, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carracedo, AngelUNSPECIFIEDorcid.org/0000-0003-1085-8986UNSPECIFIED
Amouyel, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schellenberg, Gerard D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, JulieUNSPECIFIEDorcid.org/0000-0002-4069-0259UNSPECIFIED
Seshadri, SudhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Cornelia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mather, Karen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Valle, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serrano-Rios, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orellana, AdelinaUNSPECIFIEDorcid.org/0000-0002-0204-1944UNSPECIFIED
Tarraga, LluisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, KajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huisman, MartijnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreassen, Ole A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Posthuma, DanielleUNSPECIFIEDorcid.org/0000-0001-7582-2365UNSPECIFIED
Clarimon, JordiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boada, MerceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Lambert, Jean-CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Lee, Sven J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruiz, AgustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608531
DOI: 10.1038/s41467-021-22491-8
Journal or Publication Title: Nat. Commun.
Volume: 12
Number: 1
Date: 2021
Publisher: NATURE PORTFOLIO
Place of Publication: BERLIN
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUSCEPTIBILITY LOCI; FAMILY-HISTORY; METAANALYSIS; IMMUNITY; AGEMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60853

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