Universität zu Köln

Lakshminarasimha, AmruthaBagivalu, Puvvada, Madhuri, Hammerschmidt, Matthias and Michel, Maximilian ORCID: 0000-0002-5910-5363 (2022). Leptin modulates oocyte maturation by a central and a direct pathway in zebrafish. J. Endocrinol., 254 (1). S. 1 - 13. BRISTOL: BIOSCIENTIFICA LTD. ISSN 1479-6805

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Abstract

Loss of LEPR function (LOF) in mammals leads to diverse phenotypes including morbid obesity and infertility while zebrafish show relatively minor phenotypes. This however allows the study of LEPR LOF in the absence of the detrimental effects of hyperglycemia or obesity. Here, we show evidence that leptin plays a role in the central as well as peripheral regulation of the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish. Animals with a Lepr LOF show dysregulated pituitary HPG genes as well as evidence that oocytes mature slower and/or exhibit an increased rate of atresia. In culture, Lepr LOF attenuates the effect of 17 alpha-20 beta-dihydroxy-4 pregnen-3-one in promoting germinal vesicle breakdown (GVBD) and increases the rate of GVBD as well as attenuates the rate of oocyte atresia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lakshminarasimha, AmruthaBagivalu UNSPECIFIED UNSPECIFIED UNSPECIFIED Puvvada, Madhuri UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammerschmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Michel, Maximilian UNSPECIFIED orcid.org/0000-0002-5910-5363 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-657174
DOI:	10.1530/JOE-22-0026
Journal or Publication Title:	J. Endocrinol.
Volume:	254
Number:	1
Page Range:	S. 1 - 13
Date:	2022
Publisher:	BIOSCIENTIFICA LTD
Place of Publication:	BRISTOL
ISSN:	1479-6805
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLUCOSE-HOMEOSTASIS; TISSUE DISTRIBUTION; MOLECULAR-CLONING; RECEPTOR GENE; EXPRESSION; APOPTOSIS; PUBERTY; SYSTEM; GROWTH; MEDAKA Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65717