Universität zu Köln

Otto, Moritz ORCID: 0000-0001-5407-373X, Zheng, Yichen and Wiehe, Thomas ORCID: 0000-0002-8932-2772 (2022). Recombination, selection, and the evolution of tandem gene arrays. Genetics, 221 (3). BETHESDA: GENETICS SOCIETY AMERICA. ISSN 1943-2631

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Abstract

Multigene families-immunity genes or sensory receptors, for instance-are often subject to diversifying selection. Allelic diversity may be favored not only through balancing or frequency-dependent selection at individual loci but also by associating different alleles in multicopy gene families. Using a combination of analytical calculations and simulations, we explored a population genetic model of epistatic selection and unequal recombination, where a trade-off exists between the benefit of allelic diversity and the cost of copy abundance. Starting from the neutral case, where we showed that gene copy number is Gamma distributed at equilibrium, we derived also the mean and shape of the limiting distribution under selection. Considering a more general model, which includes variable population size and population substructure, we explored by simulations mean fitness and some summary statistics of the copy number distribution. We determined the relative effects of selection, recombination, and demographic parameters in maintaining allelic diversity and shaping the mean fitness of a population. One way to control the variance of copy number is by lowering the rate of unequal recombination. Indeed, when encoding recombination by a rate modifier locus, we observe exactly this prediction. Finally, we analyzed the empirical copy number distribution of 3 genes in human and estimated recombination and selection parameters of our model.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Otto, Moritz UNSPECIFIED orcid.org/0000-0001-5407-373X UNSPECIFIED Zheng, Yichen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiehe, Thomas UNSPECIFIED orcid.org/0000-0002-8932-2772 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-657239
DOI:	10.1093/genetics/iyac052
Journal or Publication Title:	Genetics
Volume:	221
Number:	3
Date:	2022
Publisher:	GENETICS SOCIETY AMERICA
Place of Publication:	BETHESDA
ISSN:	1943-2631
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POPULATION; CONVERSION; DIVERSITY; DUPLICATIONS; NUMBER; MODEL Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65723