Borchmann, Sven (2022). Individualized patient care in nodular lymphocyte-predominant Hodgkin lymphoma. Hematol.-Am. Soc. Hematol. Educ. Program (1). S. 717 - 723. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1520-4383
Full text not available from this repository.Abstract
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma that has traditionally been consid-ered a sub group of Hodgkin lym phoma. However, mor phol ogy, sur face marker expres sion, genet ics, and clin i cal course are dif fer ent from clas sic Hodgkin lym phoma. While most patients expe ri ence indo lent dis ease with slow pro gres sion, some patients can also have more aggres sive dis ease. Nevertheless, out comes are excel lent, and excess mor tal ity due to NLPHL is at most very low. The treat ment of newly diag nosed NLPHL has his tor i cally mir rored that of clas sic Hodgkin lym phoma. However, evi dence for devi a tions from that approach has emerged over time and is discussed herein. Less evi dence is avail able for the opti mal man age ment of relapsed patients. So -called var i ant his tol ogy has recently emerged as a bio log i cal risk fac tor, pro vid ing at least a par tial expla na tion for the observed het ero ge ne ity of NLPHL. Considering var i ant his tol ogy together with other risk fac tors and care ful obser va tion of the clin i cal course of the dis ease in each patient can help to assess indi vid ual dis ease aggres sive ness. Also impor tant in this mostly indo lent dis ease are the pref-er ences of the patient and host fac tors, such as indi vid ual sus cep ti bil ity to spe cific treat ment side effects. Considering all this together can guide individualized treatment recommendations, which are paramount in this rare disease.
| Item Type: | Journal Article | ||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-657342 | ||||||||
| DOI: | 10.1182/hematology.2022000364 | ||||||||
| Journal or Publication Title: | Hematol.-Am. Soc. Hematol. Educ. Program | ||||||||
| Number: | 1 | ||||||||
| Page Range: | S. 717 - 723 | ||||||||
| Date: | 2022 | ||||||||
| Publisher: | AMER SOC HEMATOLOGY | ||||||||
| Place of Publication: | WASHINGTON | ||||||||
| ISSN: | 1520-4383 | ||||||||
| Language: | English | ||||||||
| Faculty: | Unspecified | ||||||||
| Divisions: | Unspecified | ||||||||
| Subjects: | no entry | ||||||||
| Uncontrolled Keywords: |
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/65734 |
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