Peltzer, Nieves (2022). Linear ubiquitin as a common regulator of cellular stress. FEBS J., 289 (17). S. 5176 - 5180. HOBOKEN: WILEY. ISSN 1742-4658
Full text not available from this repository.Abstract
Linear or M1-ubiquitination (Ub) is required for optimal NF-kB activation and for cell death inhibition. Using Drosophila as a model organism, Aalto et al. found that hypoxia, oxidative and mechanical stress induced M1-Ub by the HOIP homolog, LUBEL. Increased M1-Ub had a protective function driven by activation of the NF-kappa B transcription factor Relish via the Immune deficiency pathway (Imd). This protective M1-Ub was also induced upon cellular stress in colorectal cancer cells. Collectively, they propose that M1-Ub is a conserved, common response to different forms of stresses. These findings may have important implications for the use of HOIP inhibitors for cancer treatment.
| Item Type: | Journal Article | ||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-657840 | ||||||||
| DOI: | 10.1111/febs.16427 | ||||||||
| Journal or Publication Title: | FEBS J. | ||||||||
| Volume: | 289 | ||||||||
| Number: | 17 | ||||||||
| Page Range: | S. 5176 - 5180 | ||||||||
| Date: | 2022 | ||||||||
| Publisher: | WILEY | ||||||||
| Place of Publication: | HOBOKEN | ||||||||
| ISSN: | 1742-4658 | ||||||||
| Language: | English | ||||||||
| Faculty: | Unspecified | ||||||||
| Divisions: | Unspecified | ||||||||
| Subjects: | no entry | ||||||||
| Uncontrolled Keywords: |
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/65784 |
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