Grundemann, Dirk, Hartmann, Lea and Flogel, Svenja (2022). The ergothioneine transporter (ETT): substrates and locations, an inventory. FEBS Lett., 596 (10). S. 1252 - 1270. HOBOKEN: WILEY. ISSN 1873-3468

Full text not available from this repository.

Abstract

In all vertebrates including mammals, the ergothioneine transporter ETT (obsolete name OCTN1; human gene symbol SLC22A4) is a powerful and highly specific transporter for the uptake of ergothioneine (ET). ETT is not expressed ubiquitously and only cells with high ETT cell-surface levels can accumulate ET to high concentration. Without ETT, there is no uptake because the plasma membrane is essentially impermeable to this hydrophilic zwitterion. Here, we review the substrate specificity and localization of ETT, which is prominently expressed in neutrophils, monocytes/macrophages, and developing erythrocytes. Most sites of strong expression are conserved across species, but there are also major differences. In particular, we critically analyze the evidence for the expression of ETT in the brain as well as recent data suggesting that the transporter SLC22A15 may also transport ET. We conclude that, to date, ETT remains the only well-defined biomarker for intracellular ET activity. In humans, the ability to take up, distribute, and retain ET depends principally on this transporter.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Grundemann, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, LeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flogel, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-657888
DOI: 10.1002/1873-3468.14269
Journal or Publication Title: FEBS Lett.
Volume: 596
Number: 10
Page Range: S. 1252 - 1270
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1873-3468
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ORGANIC CATION TRANSPORTER; CELL LINE HCMEC/D3; CATION/CARNITINE TRANSPORTER; FUNCTIONAL EXPRESSION; TISSUE DISTRIBUTION; MESSENGER-RNA; OCTN1 SLC22A4; ANTIOXIDANT ERGOTHIONEINE; DRUG TRANSPORTER; GENESMultiple languages
Biochemistry & Molecular Biology; Biophysics; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/65788

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item