Universität zu Köln

Nettersheim, Felix Sebastian, Picard, Felix Simon Ruben ORCID: 0000-0001-7624-4704, Hoyer, Friedrich Felix and Winkels, Holger ORCID: 0000-0003-1333-2031 (2022). Immunotherapeutic Strategies in Cancer and Atherosclerosis-Two Sides of the Same Coin. Front. Cardiovasc. Med., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2297-055X

Full text not available from this repository.

Abstract

The development and clinical approval of immunotherapies has revolutionized cancer therapy. Although the role of adaptive immunity in atherogenesis is now well-established and several immunomodulatory strategies have proven beneficial in preclinical studies, anti-atherosclerotic immunotherapies available for clinical application are not available. Considering that adaptive immune responses are critically involved in both carcinogenesis and atherogenesis, immunotherapeutic approaches for the treatment of cancer and atherosclerosis may exert undesirable but also desirable side effects on the other condition, respectively. For example, the high antineoplastic efficacy of immune checkpoint inhibitors, which enhance effector immune responses against tumor cells by blocking co-inhibitory molecules, was recently shown to be constrained by substantial proatherogenic properties. In this review, we outline the specific role of immune responses in the development of cancer and atherosclerosis. Furthermore, we delineate how current cancer immunotherapies affect atherogenesis and discuss whether anti-atherosclerotic immunotherapies may similarly have an impact on carcinogenesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nettersheim, Felix Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Picard, Felix Simon Ruben UNSPECIFIED orcid.org/0000-0001-7624-4704 UNSPECIFIED Hoyer, Friedrich Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Winkels, Holger UNSPECIFIED orcid.org/0000-0003-1333-2031 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-658224
DOI:	10.3389/fcvm.2021.812702
Journal or Publication Title:	Front. Cardiovasc. Med.
Volume:	8
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2297-055X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; LOW-DENSITY-LIPOPROTEIN; TUMOR-INFILTRATING LYMPHOCYTES; PRESERVES C-PEPTIDE; MONOCLONAL-ANTIBODY; BREAST-CANCER; IMMUNE SURVEILLANCE; ANTI-CD3 ANTIBODY; CHEMOTHERAPY PLUS; INTERFERON-ALPHA Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65822