Universität zu Köln

Kowatschew, Daniel and Korsching, Sigrun, I (2022). Lamprey possess both V1R and V2R olfactory receptors, but only V1Rs are expressed in olfactory sensory neurons. Chem. Senses, 47. OXFORD: OXFORD UNIV PRESS. ISSN 1464-3553

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Abstract

The sense of smell employs some of the largest gene families in the genome to detect and distinguish a multitude of different odors. Within vertebrates, 4 major olfactory receptor families have been described; of which, only 3 (OR, TAAR-like, and V1R) were found already in lamprey, a jawless vertebrate. The forth family (V2R) was believed to have originated later, in jawed vertebrates. Here we have delineated the entire vomeronasal receptor repertoire in 3 lamprey species. We report the presence of 6 v1r and 2 v2r genes in Lethenteron camtschaticum, arctic lamprey, and Lampetra fluviatilis, river lamprey (6 and 1, respectively, in sea lamprey, Petromyzon marinus). Three v1r genes but no v2r genes were found to be expressed in olfactory sensory neurons in the characteristic sparse expression pattern. Our results show the olfactory function of some V1Rs already in lamprey and, unexpectedly, an early origin of the V2R family in the shared ancestor of jawed and jawless vertebrates. However, lamprey v2r genes appear not to have acquired an olfactory function yet, thus dissociating the evolutionary origin of the family from the onset of a function as olfactory receptor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kowatschew, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun, I UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-658238
DOI:	10.1093/chemse/bjac007
Journal or Publication Title:	Chem. Senses
Volume:	47
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1464-3553
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PETROMYZON-MARINUS; GENE-EXPRESSION; ZEBRAFISH; FAMILY; EPITHELIUM; ORIGIN; FISH; EVOLUTION; SELECTION; DOMAINS Multiple languages Behavioral Sciences; Food Science & Technology; Neurosciences; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65823