Universität zu Köln

Hildebrandt, Ximena, Ibrahim, Mohamed and Peltzer, Nieves . Cell death and inflammation during obesity: Know my methods, WAT(son). Cell Death Differ.. LONDON: SPRINGERNATURE. ISSN 1476-5403

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Abstract

Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family mediate cell death and inflammation within the adipose tissue, eventually resulting in lipid spill-over, glucotoxicity and insulin resistance. These events ultimately lead to ectopic lipid deposition, glucose intolerance and other metabolic complications with life-threatening consequences. Here we review the literature on how inflammatory responses affect metabolic processes such as energy homeostasis and insulin signalling. This review mainly focuses on the role of cell death in the adipose tissue as a key player in metabolic inflammation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hildebrandt, Ximena UNSPECIFIED UNSPECIFIED UNSPECIFIED Ibrahim, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Peltzer, Nieves UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-658514
DOI:	10.1038/s41418-022-01062-4
Journal or Publication Title:	Cell Death Differ.
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; ADIPOSE-TISSUE INFLAMMATION; INDUCED INSULIN-RESISTANCE; IKK-BETA; NONALCOHOLIC STEATOHEPATITIS; CASPASE-1 ACTIVATION; NLRP3 INFLAMMASOME; PREVENTS OBESITY; FAT DEPOTS; KINASE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65851