Universität zu Köln

Peltzer, Nieves ORCID: 0000-0002-4134-5852 and Annibaldi, Alessandro (2022). Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines, 10 (6). BASEL: MDPI. ISSN 2227-9059

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Abstract

Aberrant cell death can cause inflammation and inflammation-related diseases. While the link between cell death and inflammation has been widely established in mouse models, evidence supporting a role for cell death in the onset of inflammatory and autoimmune diseases in patients is still missing. In this review, we discuss how the lessons learnt from mouse models can help shed new light on the initiating or contributing events leading to immune-mediated disorders. In addition, we discuss how multiomic approaches can provide new insight on the soluble factors released by dying cells that might contribute to the development of such diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peltzer, Nieves UNSPECIFIED orcid.org/0000-0002-4134-5852 UNSPECIFIED Annibaldi, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-658835
DOI:	10.3390/biomedicines10061436
Journal or Publication Title:	Biomedicines
Volume:	10
Number:	6
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2227-9059
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; LINEAR UBIQUITIN; SIGNALING COMPLEX; XIAP DEFICIENCY; A20; TNF; LUBAC; ACTIVATION; INHIBITION; MUTATIONS Multiple languages Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65883