Universität zu Köln

Dooling, Vivienne, Lappas, Alexandra and Dietlein, Thomas Stefan (2022). Is canaloplasty with mitomycin c a safe procedure in myopic glaucoma? Graefes Arch. Clin. Exp. Ophthalmol., 260 (10). S. 3339 - 3348. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Purpose Myopic glaucoma patients display a considerable risk of complications following antiglaucomatous filtering surgery, e.g., trabeculectomy. Canaloplasty with mitomycin C may reduce this risk by avoiding massive overfiltration. Methods We performed retrospective analysis of 31 eyes with myopia that underwent canaloplasty modified with mitomycin C in a consecutive single-surgeon case series. Annual data and success rates were analysed. Twenty-three myopic eyes that had received conventional trabeculectomy with mitomycin C were recorded as a comparison. Results The 31 eyes with a follow-up of 40 +/- 26 months after canaloplasty had a mean spherical equivalent of- 8.4 +/- 4.5 dioptres. Intraocular pressure decreased from 32.3 +/- 9.6 mmHg (range: 17 to 58) to 16.8 +/- 8.1 mmHg (range: 5 to 44) 1 year after surgery (- 46%; p < 0.001) with a medication score reduction from 5 to 1.2 (p < 0.001). Qualified success rates (Criterion B: no revision surgery, IOP < 21 mmHg, TOP reduction > 20%) were 83% after 1 year and 61% at the 2nd and 3rd years. In 5 eyes (16%), early ocular hypotony (<= 5 mmHg) was observed. Two eyes (7%) showed transient choroidal detachment and swelling. The 23 eyes that had received trabeculectomy had success rates (Criterion B) of 91% at the 1st and 86% at the 2nd and 3rd years. Hypotony occurred in 10 eyes (44%), and 4 eyes (17%) showed choroidal detachment or macular folds. Conclusions Postoperative complications related to overfiltration were less frequent after canaloplasty with mitomycin C. Midterm data proved good efficacy. Pressure reduction, success rates and rates of medication free patients were significantly higher in trabeculectomy compared to modified canaloplasty with mitomycin C.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dooling, Vivienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Lappas, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-659316
DOI:	10.1007/s00417-022-05655-0
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	260
Number:	10
Page Range:	S. 3339 - 3348
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPEN-ANGLE GLAUCOMA; HYPOTONY MACULOPATHY; RISK-FACTORS; TRABECULECTOMY; OUTCOMES; EFFICACY Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65931