Universität zu Köln

Chiapponi, Costanza and Bruns, Christiane J. (2022). Modern molecular and imaging diagnostics in pancreatic neuroendocrine neoplasms. Chirurgie, 93 (8). S. 731 - 739. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-698X

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Abstract

Background and objective New molecular diagnostic and radiologic imaging techniques can be used to assess the extent, risk of recurrence, prognosis and response to treatment of pancreatic neuroendocrine neoplasms (pNENs). They therefore represent a decisive help in setting the indications for surgical treatment, especially in advanced stages. Methods This article presents a narrative assessment of the options and evidence for modern molecular and radiologic imaging diagnostics of pNENs based on the current literature. Results While circulating DNA, circulating tumor cells and microRNAs have not yet become established in everyday clinical practice, the current literature suggests a promising role for the so-called NETest. Recent studies demonstrated its possible importance for the surgical management of pNENs. Besides [68Ga]Ga-DOTA-SSA-PET and [18]FDG-PET, which remain the gold standards for imaging NENs, radiomics represent an exciting alternative to biopsies and will possibly play an increasingly important role in the future. Discussion There are new promising alternatives to chromogranin A, which has been clinically widespread since the 1970s despite several drawbacks, to map the extent, risk of recurrence, prognosis and response to treatment of pancreatic pNENs. In terms of personalized medicine, modern molecular and radiological diagnostics should play an increasing role for indicating and planning surgical treatment and for follow-up in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chiapponi, Costanza UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-659629
DOI:	10.1007/s00104-022-01645-4
Journal or Publication Title:	Chirurgie
Volume:	93
Number:	8
Page Range:	S. 731 - 739
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-698X
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENETS CONSENSUS GUIDELINES; CHROMOGRANIN-A; TUMORS; MANAGEMENT; UTILITY; NETEST Multiple languages Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65962