Universität zu Köln

Kuemper, Maike, Steinkamp, Joy ORCID: 0000-0001-9842-3818 and Zigrino, Paola (2022). Metalloproteinases in dermal homeostasis. Am. J. Physiol.-Cell Physiol., 323 (4). S. C1290 - 14. Rockville: AMER PHYSIOLOGICAL SOC. ISSN 1522-1563

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Abstract

Maintenance of skin homeostasis is a highly regulated and complex process involving a continuous remodeling by several extracellular matrix proteases, including metalloproteinases. The expression and activity of all metalloproteinases are under strict control, and their deregulation is often associated with diseases or chronic conditions, thereby being considered popular targets for developing new therapeutics. This review will highlight metalloproteinases of the MMP and ADAM families with functions in dermal homeostasis and give some insights into the mechanisms regulating their activity and expression. Furthermore, we discuss how the dysregulation of the most prominent family members affects dermal homeostasis by triggering disease development and influencing progression, focusing on cancer and aging. Here, recent discoveries and new approaches that target or exploit metalloproteinase activity in therapy are emphasized. The potential of naturally derived components in regulating metalloproteinase expression and activity in disease is discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuemper, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinkamp, Joy UNSPECIFIED orcid.org/0000-0001-9842-3818 UNSPECIFIED Zigrino, Paola UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660451
DOI:	10.1152/ajpcell.00450.2021
Journal or Publication Title:	Am. J. Physiol.-Cell Physiol.
Volume:	323
Number:	4
Page Range:	S. C1290 - 14
Date:	2022
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	Rockville
ISSN:	1522-1563
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MATRIX-METALLOPROTEINASE; EXTRACELLULAR-MATRIX; GROWTH-FACTOR; GENE-EXPRESSION; INTERSTITIAL COLLAGENASE; POSTTRANSCRIPTIONAL REGULATION; MACROPHAGE METALLOELASTASE; SELECTIVE-INHIBITION; MOLECULAR-MECHANISM; TISSUE INHIBITORS Multiple languages Cell Biology; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66045