Universität zu Köln

Daverkausen-Fischer, Lea and Prls, Felicitas (2022). Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol. J. Biol. Chem., 298 (7). AMSTERDAM: ELSEVIER. ISSN 1083-351X

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Abstract

The concentration of Ca2+ in the endoplasmic reticulum (ER) is critically important for maintaining its oxidizing environment as well as for maintaining luminal ATP levels required for chaperone activity. Therefore, local luminal Ca2+ concentrations and the dynamic Ca2+ flux between the different subcellular compartments are tightly controlled. Influx of Ca2+ into the ER is enabled by a reductive shift, which opens the sarcoendoplasmic reticulum calcium transport ATPase pump, building the Ca2+ gradient across the ER membrane required for ATP import. Meanwhile, Ca2+ leakage from the ER has been reported to occur via the Sec61 translocon following protein translocation. In this review, we provide an overview of the complex regulation of Ca2+ homeostasis, Ca2+ flux between subcellular compartments, and the cellular stress response (the unfolded protein response) induced upon dysregulated luminal Ca2+ metabolism. We also provide insight into the structure and gating mechanism at the Sec61 translocon and examine the role of ER-resident cochaperones in assisting the central ER-resident chaperone BiP in the control of luminal Ca2+ concentrations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Daverkausen-Fischer, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Prls, Felicitas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660762
DOI:	10.1016/j.jbc.2022.102061
Journal or Publication Title:	J. Biol. Chem.
Volume:	298
Number:	7
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1083-351X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNFOLDED PROTEIN; CELL-SURFACE; ER STRESS; CA2+ LEAK; DISULFIDE REDUCTASE; TRANSLOCON PORE; DNAJ HOMOLOG; GRP 78; CHAPERONE; BIP Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66076