Universität zu Köln

Shi, Xin ORCID: 0000-0002-6649-4045, Li, Panpan ORCID: 0000-0001-5777-0899, Liu, Hanhan and Prokosch, Verena (2022). Oxidative Stress, Vascular Endothelium, and the Pathology of Neurodegeneration in Retina. Antioxidants, 11 (3). BASEL: MDPI. ISSN 2076-3921

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Abstract

Oxidative stress (OS) is an imbalance between free radicals/ROS and antioxidants, which evokes a biological response and is an important risk factor for diseases, in both the cardiovascular system and central nervous system (CNS). The underlying mechanisms driving pathophysiological complications that arise from OS remain largely unclear. The vascular endothelium is emerging as a primary target of excessive glucocorticoid and catecholamine action. Endothelial dysfunction (ED) has been implicated to play a crucial role in the development of neurodegeneration in the CNS. The retina is known as an extension of the CNS. Stress and endothelium dysfunction are suspected to be interlinked and associated with neurodegenerative diseases in the retina as well. In this narrative review, we explore the role of OS-led ED in the retina by focusing on mechanistic links between OS and ED, ED in the pathophysiology of different retinal neurodegenerative conditions, and how a better understanding of the role of endothelial function could lead to new therapeutic approaches for neurodegenerative diseases in the retina.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shi, Xin UNSPECIFIED orcid.org/0000-0002-6649-4045 UNSPECIFIED Li, Panpan UNSPECIFIED orcid.org/0000-0001-5777-0899 UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-660793
DOI:	10.3390/antiox11030543
Journal or Publication Title:	Antioxidants
Volume:	11
Number:	3
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; FOCAL ADHESION KINASE; BLOOD-FLOW REGULATION; REACTIVE OXYGEN; HYDROGEN-PEROXIDE; L-ARGININE; TYROSINE PHOSPHORYLATION; HUMAN MICROCIRCULATION; DIABETIC-RETINOPATHY; CARDIOVASCULAR RISK Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66079