Universität zu Köln

Werra, Ursula Elisabeth Maria and Dorweiler, Bernhard (2023). Cold plasma in wound treatment-What do we know? Gefasschirurgie, 28 (1). S. 7 - 15. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1434-3932

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Abstract

Despite all efforts not all wounds can be healed by guideline-conform wound treatment, even after revascularization, with orthopedic footwear and control of all risk factors. This often long-term treatment not only burdens the patients but also costs a lot of money. Therefore, additional physical treatment methods, such as the use of cold plasma are becoming increasingly more popular in the treatment of chronic wounds. On 15 July 2021, the German Federal Joint Committee (G-BA) accepted the clinical trial application for the use of cold plasma treatment.The active components of cold plasma are electromagnetic radiation, free radicals, UV radiation, ions and electrons. The mechanism of action is based on damaging bacterial cells and thereby decontaminating the wound as well as positive interactions with epithelial cells, endothelial cells, immune cells and keratinocytes. In addition, pH values are lowered and angiogenesis as well as cellular oxygen metabolism are stimulated, which contributes to improved wound healing.The current evidence situation is still weak and heterogeneous as the results are sometimes contradictory. Additionally, a direct comparison between them is difficult because of the different plasma sources (helium, argon and atmospheric air) and the different production procedures. New well-designed studies confirmed the previous positive results regarding improved wound healing with significant results, also with respect to the complete healing of wounds. Therefore, further high-quality studies should be carried out to create a robust data situation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Werra, Ursula Elisabeth Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorweiler, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-661801
DOI:	10.1007/s00772-022-00960-8
Journal or Publication Title:	Gefasschirurgie
Volume:	28
Number:	1
Page Range:	S. 7 - 15
Date:	2023
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1434-3932
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATMOSPHERIC ARGON PLASMA Multiple languages Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66180