Menghesha, Hruy, Doerr, Fabian, Schlachtenberger, Georg, Estremadoyro, Andres Amorin, Toepelt, Karin, Wahlers, Thorsten, Hekmat, Khosro and Heldwein, Matthias (2022). Neoadjuvant chemoimmunotherapy as a potential therapeutic option in NSCLC UICC stage IIIA with multilevel N2 disease. Respir. Med. Case Rep., 39. AMSTERDAM: ELSEVIER. ISSN 2213-0071
Full text not available from this repository.Abstract
Lung Cancer is still one of the leading causes for cancer related death worldwide. The determina-tion of an adequate therapeutic approach requests a precise staging, which contains computed to-mography (CT) of the thorax, positron emission tomography computed tomography (PET-CT), cerebral magnetic resonance imaging (cMRI) and pulmonary function testing as well as the pa-tient's opinion. In UICC stages I and II, if there is functional operability and technical resectabil-ity, the treatment of choice is primary surgery followed by adjuvant therapy depending on lymph node status, while patients in the metastatic stage IV, or with locally advanced, nonresectable dis-ease are more likely to receive definitive chemoradiation therapy. The UICC Stage III (8th edi-tion) combines a heterogeneous group of patients that remains the focus of discussion regarding the optimal therapeutic regimen, which ranges from primary surgical care to a neoadjuvant ther-apeutic approach, to definitive conservative treatment. Since March 2020, we have been treating a patient on an interdisciplinary basis who initially had a UICC stage IIIA multilevel N-2 pul-monary adenocarcinoma and finally underwent successful surgery after a very good response to neoadjuvant chemoimmunotherapy. Our latest follow-up showed no evidence of recurrence. Sim-ilar to current ongoing studies our case shows, that neoadjuvant immunotherapy is a reasonable alternative to conventional neoadjuvant chemotherapy.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-662440 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.rmcr.2022.101728 | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Respir. Med. Case Rep. | ||||||||||||||||||||||||||||||||||||
| Volume: | 39 | ||||||||||||||||||||||||||||||||||||
| Date: | 2022 | ||||||||||||||||||||||||||||||||||||
| Publisher: | ELSEVIER | ||||||||||||||||||||||||||||||||||||
| Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||||||||||||||
| ISSN: | 2213-0071 | ||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/66244 |
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