Universität zu Köln

Vaddavalli, Pavana Lakshmi and Schumacher, Bjoern (2022). The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet., 38 (6). S. 598 - 613. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1362-4555

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Abstract

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most frequently mutated gene in human cancers. p53 plays a central role in responding to DNA damage and determines the outcome of the DNA damage checkpoint response by regulating cell cycle arrest and apoptosis. As a consequence of this function, dysfunctional p53 results in cells that, despite a damaged genome, continue to proliferate thus fueling malignant transformation. New insights have recently been gained into the complexity of the p53 regulation of the DNA damage response (DDR) and how it impacts a wide variety of cellular processes. In addition to cell-autonomous signaling mechanisms, non-cell-autonomous regulatory inputs influence p53 activity, which in turn can have systemic consequences on the organism. New inroads have also been made toward therapeutic targeting of p53 that for a long time has been anticipated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vaddavalli, Pavana Lakshmi UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662559
DOI:	10.1016/j.tig.2022.02.010
Journal or Publication Title:	Trends Genet.
Volume:	38
Number:	6
Page Range:	S. 598 - 613
Date:	2022
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1362-4555
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WILD-TYPE P53; TUMOR-SUPPRESSOR; MUTANT P53; ELEGANS P53; MOUSE MODEL; LIFE-SPAN; APOPTOSIS; CELLS; GENE; RESTORATION Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66255