Universität zu Köln

Koehler, Felix C., Di Cristanziano, Veronica, Spath, Martin R., Hoyer-Allo, K. Johanna R., Wanken, Manuel, Muller, Roman-Ulrich and Burst, Volker ORCID: 0000-0002-0256-6628 (2022). The kidney in hantavirus infection-epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management. Clin. Kidney J., 15 (7). S. 1231 - 1253. OXFORD: OXFORD UNIV PRESS. ISSN 2048-8513

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Abstract

Hantavirus-induced diseases are emerging zoonoses with endemic appearances and frequent outbreaks in different parts of the world. In humans, hantaviral pathology is characterized by the disruption of the endothelial cell barrier followed by increased capillary permeability, thrombocytopenia due to platelet activation/depletion and an overactive immune response. Genetic vulnerability due to certain human leukocyte antigen haplotypes is associated with disease severity. Typically, two different hantavirus-caused clinical syndromes have been reported: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). The primarily affected vascular beds differ in these two entities: renal medullary capillaries in HFRS caused by Old World hantaviruses and pulmonary capillaries in HCPS caused by New World hantaviruses. Disease severity in HFRS ranges from mild, e.g. Puumala virus-associated nephropathia epidemica, to moderate, e.g. Hantaan or Dobrava virus infections. HCPS leads to a severe acute respiratory distress syndrome with high mortality rates. Due to novel insights into organ tropism, hantavirus-associated pathophysiology and overlapping clinical features, HFRS and HCPS are believed to be interconnected syndromes frequently involving the kidneys. As there are no specific antiviral treatments or vaccines approved in Europe or the USA, only preventive measures and public awareness may minimize the risk of hantavirus infection. Treatment remains primarily supportive and, depending on disease severity, more invasive measures (e.g., renal replacement therapy, mechanical ventilation and extracorporeal membrane oxygenation) are needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koehler, Felix C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Spath, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer-Allo, K. Johanna R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wanken, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Muller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Burst, Volker UNSPECIFIED orcid.org/0000-0002-0256-6628 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-663639
DOI:	10.1093/ckj/sfac008
Journal or Publication Title:	Clin. Kidney J.
Volume:	15
Number:	7
Page Range:	S. 1231 - 1253
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2048-8513
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PUUMALA VIRUS-INFECTION; CYTOKINE RELEASE SYNDROME; ENDOTHELIAL GROWTH-FACTOR; LETHAL DISEASE-MODEL; CD8(+) T-CELLS; HEMORRHAGIC-FEVER; RENAL SYNDROME; PULMONARY SYNDROME; NEPHROPATHIA-EPIDEMICA; HANTAAN VIRUS Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66363