Universität zu Köln

Sirokay, Judith and Mauch, Cornelia (2022). Melanoma microenvironment-impact of modern therapies. Dermatologie, 73 (12). S. 907 - 915. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7013

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Abstract

Background A considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies. Objectives An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given. Methods Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed. Results The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma. Conclusion Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sirokay, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-664031
DOI:	10.1007/s00105-022-05078-2
Journal or Publication Title:	Dermatologie
Volume:	73
Number:	12
Page Range:	S. 907 - 915
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7013
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-ASSOCIATED MACROPHAGES; PD-1 EXPRESSION; INFLAMMATION; NIVOLUMAB; CANCER; CELLS Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66403