Universität zu Köln

Behrens, Amelie L., Dihlmann, Susanne, Grond-Ginsbach, Caspar, Peters, Andreas S., Dorweiler, Bernhard ORCID: 0000-0002-8262-8381, Boeckler, Dittmar and Erhart, Philipp ORCID: 0000-0002-4964-2448 (2022). Gene Expression Profiling in Abdominal Aortic Aneurysms. J. Clin. Med., 11 (12). BASEL: MDPI. ISSN 2077-0383

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Abstract

Gene expression profiling of abdominal aortic aneurysms (AAA) indicates that chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components are involved in disease development and progression. This study investigates intra- and interpersonal RNA genome-wide expression profiling differences (Illumina HumanHT-12, BeadCHIP expression) of 24 AAA biopsies from 12 patients using a single gene and pathway (GeneOntology, GO enrichment) analysis. Biopsies were collected during open surgical AAA repair and according to prior finite element analysis (FEA) from regions with the highest and lowest wall stress. Single gene analysis revealed a strong heterogeneity of RNA expression parameters within the same and different AAA biopsies. The pathway analysis of all samples showed significant enrichment of genes from three different signaling pathways (integrin signaling pathway: fold change FC 1.63, p = 0.001; cholecystokinin receptor pathway: FC 1.60, p = 0.011; inflammation mediated by chemokine signaling pathway: FC 1.45, p = 0.028). These results indicate heterogeneous gene expression patterns within the AAA vascular wall. Single biopsy investigations do not permit a comprehensive characterization of activated molecular processes in AAA disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behrens, Amelie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dihlmann, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Grond-Ginsbach, Caspar UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Andreas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorweiler, Bernhard UNSPECIFIED orcid.org/0000-0002-8262-8381 UNSPECIFIED Boeckler, Dittmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Erhart, Philipp UNSPECIFIED orcid.org/0000-0002-4964-2448 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-664070
DOI:	10.3390/jcm11123260
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	12
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOOL Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66407