Universität zu Köln

Buettner, Reinhard and Gueltekin, Sibel Elif (2022). Molecular diagnostics in odontogenic tumors. Pathologie, 43 (SUPPL 1). S. 81 - 86. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7196

Full text not available from this repository.

Abstract

Background Odontogenic tumors (OTs) are rare, with an estimated incidence rate of less than 0.5 cases per 100,000 per year. The causes of OTs remain unclear. Nonetheless, the majority of OTs seem to arise de novo, without an apparent causative factor. Although the etiopathogenesis of most OTs remains unclear, there have been some recent advances in understanding the genetic basis relating to specific histologies and clinical features. Molecular analyses performed by different techniques, including Sanger sequencing, next-generation sequencing, and allele-specific PCR, have uncovered mutations in genes related to the oncogenic MAPK/ERK signaling pathway. Genetic mutations in these pathway genes have been reported in epithelial and mixed OTs, in addition to odontogenic carcinomas and sarcomas. Notably, B-RAF proto-oncogene serine/threonine kinase (BRAF) and KRAS proto-oncogene GTPase (KRAS) pathogenic mutations have been reported in a high proportion of ameloblastoma and ameloblastoma-related tumors and adenomatoid odontogenic tumors, respectively. Objective To discuss how molecular profiling aids in diagnostic classification of odontogenic tumors. Conclusion Molecular profiling of odontogenic tumors helps to identify patients for neoadjuvant therapies and reduces postoperative morbidity

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Gueltekin, Sibel Elif UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-664347
DOI:	10.1007/s00292-022-01152-7
Journal or Publication Title:	Pathologie
Volume:	43
Number:	SUPPL 1
Page Range:	S. 81 - 86
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7196
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUTATIONS Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66434