Universität zu Köln

Thevis, M., Walpurgis, Katja and Thomas, A. (2023). DropWise: current role and future perspectives of dried blood spots (DBS), blood microsampling, and their analysis in sports drug testing. Crit. Rev. Clin. Lab. Sci., 60 (1). S. 41 - 63. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1549-781X

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Abstract

For decades, blood testing has been an integral part of routine doping controls. The breadth of information contained in blood samples has become considerably more accessible for anti-doping purposes over the last 10 years through technological advancements regarding analytical instrumentation as well as enhanced sample collection systems. Particularly, microsampling of whole blood and serum, for instance as dried blood spots (DBS), has opened new avenues in sports drug testing and substantially increased the availability and cost-effectiveness of doping control specimens. Thus, microvolume blood specimens possess the potential to improve monitoring of blood hormone and drug levels, support evaluation of circulating drug concentrations in competition, and enhance the stability of labile markers and target analytes in blood passport analyses as well as peptide hormone and steroid ester detection. Further, the availability of the fraction of lysed erythrocytes for anti-doping purposes warrants additional investigation, considering the sequestering capability of red blood cells (RBCs) for certain substances, as a complementary approach in support of the clean sport.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walpurgis, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-664538
DOI:	10.1080/10408363.2022.2103085
Journal or Publication Title:	Crit. Rev. Clin. Lab. Sci.
Volume:	60
Number:	1
Page Range:	S. 41 - 63
Date:	2023
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1549-781X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-HORMONE ABUSE; DOPING CONTROL ANALYSIS; WHOLE-BLOOD; QUANTITATIVE BIOANALYSIS; TESTOSTERONE ESTERS; MAJOR METABOLITES; HEMATOCRIT BIAS; AICA-RIBOSIDE; LC-MS/MS; URINE Multiple languages Medical Laboratory Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66453