Universität zu Köln

Escola, Jordi Kuehne, Deuschl, Cornelius, Junker, Andreas ORCID: 0000-0002-8063-9765, Dusse, Fabian ORCID: 0000-0001-7762-6966, Pul, Refik ORCID: 0000-0002-8940-9317, Kleinschnitz, Christoph ORCID: 0000-0002-1650-8875, Koehrmann, Martin and Frank, Benedikt (2022). MOG antibody-associated encephalomyelitis mimicking bacterial meningomyelitis following ChAdOx1 nCoV-19 vaccination: a case report. Ther. Adv. Neurol. Disord., 15. LONDON: SAGE PUBLICATIONS LTD. ISSN 1756-2864

Full text not available from this repository.

Abstract

We report a case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalomyelitis following vector-based vaccination against SARS-CoV-2 that mimicked bacterial meningomyelitis upon initial presentation. A 43-year-old woman who had received a first dose of ChAdOx1 nCoV-19 (Vaxzevria; Astra Zeneca, UK Limited) 9 days earlier presented with subacute sensorimotor paraparesis, urinary retention, headache, meningism, and fever. Clinical findings and cerebrospinal fluid (CSF) features were highly suggestive of bacterial infection; however, despite receiving broad anti-infective treatment alongside with high-dose glucocorticoids, symptoms deteriorated. Imaging findings and the detection of immunoglobulin G against MOG substantiated diagnosis of an anti-MOG associated disorder. Treatment with high-dose intravenous (IV) methylprednisolone and plasma exchange resulted in substantial clinical improvement, which sustained under monthly regimen of IV Tocilizumab at 3-month follow-up. Awareness of this post-vaccinal presentation of a rare autoimmune disorder is important to not miss potential treatment options.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Escola, Jordi Kuehne UNSPECIFIED UNSPECIFIED UNSPECIFIED Deuschl, Cornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Junker, Andreas UNSPECIFIED orcid.org/0000-0002-8063-9765 UNSPECIFIED Dusse, Fabian UNSPECIFIED orcid.org/0000-0001-7762-6966 UNSPECIFIED Pul, Refik UNSPECIFIED orcid.org/0000-0002-8940-9317 UNSPECIFIED Kleinschnitz, Christoph UNSPECIFIED orcid.org/0000-0002-1650-8875 UNSPECIFIED Koehrmann, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-664754
DOI:	10.1177/17562864211070684
Journal or Publication Title:	Ther. Adv. Neurol. Disord.
Volume:	15
Date:	2022
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1756-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICA SPECTRUM DISORDERS; DISEASE Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66475