Universität zu Köln

Keutmann, Matthias, Hermes, Gabriele, Meinberger, Denise ORCID: 0000-0002-7786-6000, Roth, Annika, Stemler, Jannik, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Klatt, Andreas R. and Streichert, Thomas (2022). The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Beneficial effects of vitamin D on COVID-19 progression have been discussed in several studies. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, and evidence shows that LL-37 can antagonize SARS-CoV-2. Therefore, we investigated the association between LL-37 and vitamin D serum levels and the severity of COVID-19. To this end, 78 COVID-19 patients were divided into 5 groups according to disease severity. We determined serum levels of LL-37, vitamin D, and routine laboratory parameters. We demonstrated a correlation of CRP, IL-6, PCT, leukocyte count, and LDH with the severity of COVID-19. Our study did not demonstrate a direct relationship between serum levels of LL-37 and vitamin D and the severity of COVID-19. LL-37 is produced by granulocytes and released at the site of inflammation. Therefore, the analysis of LL-37 in broncho-alvelolar lavage rather than in patient serum seems critical. However, since LL-37 is produced by granulocytes, we determined serum LL-37 levels as a function of leukocyte count. The LL-37/leukocyte count ratio correlates highly significantly inversely proportional with COVID-19 severity. Our results indicate that the LL-37/leukocyte count ratio could be used to assess the risk of COVID-19 progression as early as hospital admission.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Keutmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermes, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinberger, Denise UNSPECIFIED orcid.org/0000-0002-7786-6000 UNSPECIFIED Roth, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Stemler, Jannik UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED orcid.org/0000-0001-9599-3137 UNSPECIFIED Klatt, Andreas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665319
DOI:	10.1038/s41598-022-13260-8
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIMICROBIAL PEPTIDE LL-37; VITAMIN-D; HUMAN CATHELICIDIN; SARS-COV-2; INFECTION; RECEPTOR; HCAP-18; CELLS; GENE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66531