Universität zu Köln

Theobald, Sebastian J. and Rybniker, Jan (2022). Monocyte-crosstalk drives interferon-mediated signaling following SARS-CoV-2 exposure. Mol. Syst. Biol., 18 (9). HOBOKEN: WILEY. ISSN 1744-4292

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Abstract

Cells of the innate immune system represent the first line of defense against SARS-CoV-2 and play an essential role in activating adaptive immunity, which mediates long-term protection. In addition, the same cells are key drivers of tissue damage by causing the hyperinflammatory state and cytokine storm that makes COVID-19 a deadly disease. Thus, careful dissection of the host-pathogen interaction on a cellular level is essential to understanding SARS-CoV-2 pathogenesis and developing new treatment modalities against COVID-19. In their recent work, Goffinet and colleagues (Kazmierski et al, 2022) investigate the cell-intrinsic responses of human primary peripheral blood mononuclear cells (PBMCs) exposed to SARS coronaviruses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Theobald, Sebastian J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rybniker, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665592
DOI:	10.15252/msb.202211256
Journal or Publication Title:	Mol. Syst. Biol.
Volume:	18
Number:	9
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1744-4292
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66559