Universität zu Köln

Bredow, Kathrin, Bluemcke, Britta, Schneider, Stephanie, Puesken, Michael, Schmutzler, Rita and Rhiem, Kerstin (2022). Long-term survival of a BRCA2 mutation carrier following second ovarian cancer relapse using PARPi therapy: A case report. Mol. Clin. Oncol., 17 (3). ATHENS: SPANDIDOS PUBL LTD. ISSN 2049-9469

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Abstract

BRCA1/2 mutation carriers have lifelong increased risks of developing breast and ovarian cancer. Due to the lack of efficient ovarian cancer screening, patients mainly present when the tumors are at an advanced stage, and the long-term survival is poor. The application of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) has been used in personalized cancer treatment. Specific strategies to improve the outcome of patients are available and mainly include targeting of BRCA1 or BRCA2 mutations. The aim of the present study was to report the case of a 67-year old BRCA2 mutation carrier, who was enrolled in 2010 in one of the first PARPi studies (ICEBERG2). The patient exhibited second ovarian cancer (OC) relapse following a platinum-free interval of 5 months. The third-line treatment with olaparib monotherapy was initiated in January 2011, without prior surgery or chemotherapy, and achieved a persistent response. The patient demonstrated an unprecedented long-term survival of >9 years under PARPi monotherapy after the second relapse of OC. The data of the present case report support the use of PARPi as a well-tolerated and effective long-term treatment, even for patients with unfavourable prognostic characteristics, such as platinum resistance, without immediately preceding optimal cytoreduction. However, further studies are required to provide more insight into the selection of patients for favourable maintenance treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bredow, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bluemcke, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Puesken, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665745
DOI:	10.3892/mco.2022.2570
Journal or Publication Title:	Mol. Clin. Oncol.
Volume:	17
Number:	3
Date:	2022
Publisher:	SPANDIDOS PUBL LTD
Place of Publication:	ATHENS
ISSN:	2049-9469
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAINTENANCE THERAPY; DOUBLE-BLIND; PLATINUM; WOMEN; CHEMOTHERAPY; INHIBITORS; BREAST; TRIAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66574