Universität zu Köln

Thevis, Mario, Goergens, Christian, Guddat, Sven, Thomas, Andreas and Geyer, Hans . Mass spectrometry in sports drug testing-Analytical approaches and the athletes' exposome. Scand. J. Med. Sci. Sports. HOBOKEN: WILEY. ISSN 1600-0838

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Abstract

Test methods in anti-doping, most of which rely on the most modern mass spectrometric instrumentation, undergo continuous optimization in order to accommodate growing demands as to comprehensiveness, sensitivity, retrospectivity, cost-effectiveness, turnaround times, etc. While developing and improving analytical approaches is vital for appropriate sports drug testing programs, the combination of today's excellent analytical potential and the inevitable exposure of humans to complex environmental factors, specifically chemicals and drugs at the lowest levels, has necessitated dedicated research, particularly into the elite athlete's exposome. Being subjected to routine doping controls, athletes frequently undergo blood and/or urine tests for a plethora of drugs, chemicals, corresponding metabolic products, and various biomarkers. Due to the applicable anti-doping regulations, the presence of prohibited substances in an athlete's organism can constitute an anti-doping rule violation with severe consequences for the individual's career (in contrast to the general population), and frequently the question of whether the analytical data can assist in differentiating scenarios of 'doping' from 'contamination through inadvertent exposure' is raised. Hence, investigations into the athlete's exposome and how to distinguish between deliberate drug use and potential exposure scenarios have become a central topic of anti-doping research, aiming at supporting and consolidating the balance between essential analytical performance characteristics of doping control test methods and the mandate of protecting the clean athlete by exploiting new strategies in sampling and analyzing specimens for sports drug-testing purposes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergens, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Guddat, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-666039
DOI:	10.1111/sms.14228
Journal or Publication Title:	Scand. J. Med. Sci. Sports
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUTRITIONAL SUPPLEMENTS; FOOD CONTAMINATION; CLOMIPHENE CITRATE; DOPING CONTROL; CLENBUTEROL; EXCRETION; MELDONIUM; RISK; ACETAZOLAMIDE; MANAGEMENT Multiple languages Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66603