Universität zu Köln

Recker, Florian ORCID: 0000-0001-9135-4338, Weber, Eva C., Strizek, Brigitte, Geipel, Annegret, Berg, Christoph and Gembruch, Ulrich ORCID: 0000-0001-8284-4669 (2022). Management and outcome of prenatal absent pulmonary valve syndrome. Arch. Gynecol. Obstet., 306 (5). S. 1449 - 1455. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

Objective The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging. Methods A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as absent pulmonary valve syndrome, prenatal APVS and APVS/outcome. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results. Results Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1-47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5-42.3%). Conclusion The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Recker, Florian UNSPECIFIED orcid.org/0000-0001-9135-4338 UNSPECIFIED Weber, Eva C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Strizek, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-666324
DOI:	10.1007/s00404-022-06397-4
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	306
Number:	5
Page Range:	S. 1449 - 1455
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONGENITAL ABSENCE; DIAGNOSIS; ASSOCIATIONS; TETRALOGY; FALLOT Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66632