Universität zu Köln

Ng, Philipp, Pinho, Ana Rita ORCID: 0000-0001-9815-7484, Gomes, Maria C., Demidov, Yan, Krakor, Eva, Grume, Daniela, Herb, Marc ORCID: 0000-0002-7533-0288, Le, Khan, Mano, Joao, Mathur, Sanjay and Maleki, Hajar (2022). Fabrication of Antibacterial, Osteo-Inductor 3D Printed Aerogel-Based Scaffolds by Incorporation of Drug Laden Hollow Mesoporous Silica Microparticles into the Self-Assembled Silk Fibroin Biopolymer. Macromol. Biosci., 22 (4). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1616-5195

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Abstract

In this study, the novel biomimetic aerogel-based composite scaffolds through a synergistic combination of wet chemical synthesis and advanced engineering approaches have successfully designed. To this aim, initially the photo-crosslinkable methacrylated silk fibroin (SF-MA) biopolymer and methacrylated hollow mesoporous silica microcapsules (HMSC-MA) as the main constituents of the novel composite aerogels were synthesized. Afterward, by incorporation of drug-loaded HMSC-MA into the self-assembled SF-MA, printable gel-based composite inks are developed. By exploiting micro-extrusion-based three-dimensional (3D) printing, SF-MA-HMSC composite gels are printed by careful controlling their viscosity to provide a means to control the shape fidelity of the resulted printed gel constructs. The developed scaffold has shown a multitude of interesting biophysical and biological performances. Namely, thanks to the photo-crosslinking of the gel components during the 3D printing, the scaffolds become mechanically more stable than the pristine SF scaffolds. Also, freeze-casting the printed constructs generates further interconnectivity in the printed pore struts resulting in the scaffolds with hierarchically organized porosities necessary for cell infiltration and growth. Importantly, HMSC incorporated scaffolds promote antibacterial drug delivery, cellular ingrowth and proliferation, promoting osteoblastic differentiation by inducing the expression of osteogenic markers and matrix mineralization. Finally, the osteoconductive, -inductive, and anti-infective composite aerogels are expected to act as excellent bone implanting materials with an extra feature of local and sustained release of drug for efficient therapy of bone-related diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ng, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinho, Ana Rita UNSPECIFIED orcid.org/0000-0001-9815-7484 UNSPECIFIED Gomes, Maria C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Demidov, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Krakor, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Grume, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Herb, Marc UNSPECIFIED orcid.org/0000-0002-7533-0288 UNSPECIFIED Le, Khan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mano, Joao UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Maleki, Hajar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-667039
DOI:	10.1002/mabi.202100442
Journal or Publication Title:	Macromol. Biosci.
Volume:	22
Number:	4
Date:	2022
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1616-5195
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIFFERENTIATION; TISSUE; OSTEOGENESIS; STIMULATION; DELIVERY; IONS Multiple languages Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66703