Universität zu Köln

Li, Qinjie, Sun, Xiaokang, Cui, Liang, Zhong, Yuan, Wang, Beiyun, Miao, Ya, Hu, Xiaochen ORCID: 0000-0003-4126-673X and Guo, Qihao (2022). Alterations in metamemory capacity and neural correlates in a subtype of subjective cognitive decline. NeuroImage-Clin., 36. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Backgrounds: Subjective cognitive decline (SCD), one of the important clinical indicators for preclinical Alz-heimer's disease (AD), is primarily defined as self-perceived cognitive decline without objective evidence for cognitive impairment. However, the accuracy of their self-evaluation of cognition is unclear. This study sought to investigate the capacity for self-evaluation of own cognitive performance in SCD by applying an objective metamemory paradigm. Methods: 147 individuals with SCD were classified into four subgroups by their subjective feeling of worse performance than peers or not (P+/-) and whether they have objectively slight cognitive impairment compared to normative data (S+/-). Metamemory scores, the amplitude of the low-frequency fluctuation (ALFF), fractional low-frequency fluctuation amplitude (fALFF), and cortical thickness were compared among four subgroups. Partial correlations between neuropsychological scores and neuroimaging measures were examined, controlling for age, sex, and education years. Results: SCD S+P-showed the worst performance in short-term delayed recall and the worst metamemory per-formance, indicated by the highest value in the degree of confidence of short-term delayed recall (DOC-N4) and long-term cued recall (DOC-N6) and the worst value in relative accuracy of judgments of short-term delayed recall (ROJ-N4). ALFF values in the bilateral superior medial frontal and olfactory cortices and the left superior orbitofrontal gyrus cortex were significantly higher in SCD P-compared with SCD P+ groups (all P < 0.05, FWE-corrected, cluster-wise level). A significant S x P interaction effect in the left hippocampus and middle cingulate cortex was found for the fALFF signals (all P < 0.05, FWE-corrected, cluster-wise level). Significant interaction and main effects on cortical thickness were reported. The parahippocampal and posterior cingulate cortices were significantly decreased in SCD S+P-(all P < 0.05). Conclusion: SCD S+P-showed the worst episodic memory performance, altered metamemory capacity (over-confidence and less accuracy of judgment), and altered neuroimaging measures, though they had feelings of similar performance with peers. Our results indicate that metamemory capacity is affected in a subtype of SCD with reduced cortical thickness and intensity of regional spontaneous activity in key areas for metamemory processing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Qinjie UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Xiaokang UNSPECIFIED UNSPECIFIED UNSPECIFIED Cui, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhong, Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Beiyun UNSPECIFIED UNSPECIFIED UNSPECIFIED Miao, Ya UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED orcid.org/0000-0003-4126-673X UNSPECIFIED Guo, Qihao UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-667217
DOI:	10.1016/j.nicl.2022.103255
Journal or Publication Title:	NeuroImage-Clin.
Volume:	36
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; SELF-AWARENESS; ANOSOGNOSIA; DEMENTIA; ASSOCIATION; METACOGNITION; PREDICTIONS; COMPLAINTS Multiple languages Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66721