Universität zu Köln

Brunner, Andrea ORCID: 0000-0002-3245-8935, Kruis, Wolfgang, Schoemig-Markiefka, Birgid, Morgenstern, Julia, Engels, Marianne, Buettner, Reinhard and Forner, Dirk Michael ORCID: 0000-0002-5068-3933 (2022). Prevalence of abnormal Pap smear results in inflammatory bowel disease: a prospective study. J. Cancer Res. Clin. Oncol., 148 (11). S. 3071 - 3080. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

Purpose Development of malignancy is a pending threat for patients with inflammatory bowel disease (IBD). Aim of this study was to analyze cervical dysplasia and infection with human papilloma virus (HPV) in patients with IBD. Methods This was a prospective, single center cohort study in Germany. Consecutive IBD patients admitted to the Department of Gastroenterology were sent to Gynecology, where a questionnaire was answered and gynecological examinations including a smear for cytology and HPV were taken. Participants of a general screening program constituted controls. Descriptive statistics, 95% confidence intervals and odds ratios were calculated. Results A total of 101 patients were recruited of which 99 patients participated. Analysis showed a significant (p = 0.05) difference between the prevalence of abnormal smears in patients with (22%) and without (6%) immunosuppressive therapy, while the latter had cervical abnormalities comparable with healthy controls (5%). All immunosuppressants showed similarly high risks for abnormal smear results. Only 11/99 (11%) patients had positive high-risk HPV tests, which is comparable with general population. Conclusion The prevalence of abnormal cervical smears is higher in IBD patients compared to healthy individuals, but the difference is confined to patients with IBD and immunosuppressive therapy. Annual screening is advisable.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brunner, Andrea UNSPECIFIED orcid.org/0000-0002-3245-8935 UNSPECIFIED Kruis, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemig-Markiefka, Birgid UNSPECIFIED UNSPECIFIED UNSPECIFIED Morgenstern, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Engels, Marianne UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Forner, Dirk Michael UNSPECIFIED orcid.org/0000-0002-5068-3933 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-667788
DOI:	10.1007/s00432-021-03909-8
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	148
Number:	11
Page Range:	S. 3071 - 3080
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-PAPILLOMAVIRUS; CERVICAL-CANCER; OPPORTUNISTIC INFECTIONS; WOMEN; RISK; HPV; DYSPLASIA; NEOPLASIA; PREVENTION; IBD Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66778