Universität zu Köln

Stegmann, Sarah K., Kuhl, Saskia, Im, Nam Gyu, Goertz, Lukas, Goldbrunner, Roland and Timmer, Marco (2022). Death Receptor 6 as a Prognostic Marker in Low-grade Glioma. Anticancer Res., 42 (3). S. 1237 - 1246. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background/Aim: Low-grade gliomas (LGG) are heterogenous tumours, causing variable survivals in patients. Identifying molecular markers for a more accurate prognosis is, therefore, important. Since death receptor 6 (DR6) is upregulated in gliomas and shows an aberrant signalling network, we tested its suitability as a prognostic marker. Materials and Methods: DR6 was investigated in patient samples via PCR and western blot. Clinical data were 'brain lower grade glioma' dataset. Results: DR6 was found to be enhanced in LGG and its expression increased in recurrent LGG. The receptor showed a protective effect in primary LGG with a significantly elongated progression-free survival that was confirmed in the TCGA study. This effect was reversed in relapsed LGG in which cases with high DR6 expression reveal a shorter overall survival. Conclusion: DR6 is an interesting candidate for further studies regarding its effect as a prognostic marker, playing an opposing role in primary and relapsed LGG.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stegmann, Sarah K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhl, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Im, Nam Gyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-668055
DOI:	10.21873/anticanres.15591
Journal or Publication Title:	Anticancer Res.
Volume:	42
Number:	3
Page Range:	S. 1237 - 1246
Date:	2022
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR-ALPHA; APOPTOSIS-INDUCING LIGAND; CENTRAL-NERVOUS-SYSTEM; EXPRESSION; TNF; METASTASIS; SURVIVAL; CANCER; TUMORS; DR6 Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66805