Universität zu Köln

Zaeske, Charlotte ORCID: 0000-0003-3746-8523, Brueggemann, Gert-Peter, Willwacher, Steffen, Maehlich, Daniela, Maintz, David and Bratke, Grischa ORCID: 0000-0002-5696-9828 (2022). The behaviour of T2*and T2 relaxation time in extrinsic foot muscles under continuous exercise: A prospective analysis during extended running. PLoS One, 17 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objectives Previous studies on T2* and T2 relaxation time of the muscles have shown that exercise leads to an initial increase, presumably representing different intramuscular physiological processes such as increase in intracellular volume or blood oxygenation level dependent effects with a subsequent decrease after cessation of exercise. Their behaviour during prolonged exercise is still unknown but could provide important information for example about the pathophysiology of overuse injuries. The aim of this study was to evaluate the temporal course of T2* and T2 relaxation time in extrinsic foot muscles during prolonged exercise and determine the optimal mapping technique. Methods Ten participants had to run a total of 75 minutes at their individual highest possible running speed, with interleaved MR scans at baseline and after 2.5, 5, 10, 15, 45 and 75 minutes. The examined extrinsic foot muscles were manually segmented, and relaxation time were analysed regarding its respective time course. Results T2* and T2 relaxation time showed an initial increase, followed by a plateau phase between 2.5 and 15 minutes and a subsequent decrease. For the T2* relaxation time, this pattern was also apparent, but less pronounced, with more muscles not reaching significance (p<0.05) when comparing different time points. Conclusions T2* and T2 relaxation time showed a similar course with an initial rapid increase, a plateau phase and a subsequent decrease under prolonged exercise. Moderate but long-term muscular activity appears to have a weaker effect on T2* relaxation time than on T2 relaxation time.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zaeske, Charlotte UNSPECIFIED orcid.org/0000-0003-3746-8523 UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Willwacher, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Maehlich, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Bratke, Grischa UNSPECIFIED orcid.org/0000-0002-5696-9828 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669290
DOI:	10.1371/journal.pone.0264066
Journal or Publication Title:	PLoS One
Volume:	17
Number:	2
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE IMAGES; SKELETAL-MUSCLE; LACTATE KINETICS; FAST-TWITCH; INTENSITY; MRI; T-2-ASTERISK; HYPEREMIA; PERFUSION; CONTRAST Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66929