Universität zu Köln

Ney, Svenja, Ihle, Peter, Ruhnke, Thomas, Gunster, Christian, Michels, Guido, Seuthe, Katharina, Hellmich, Martin and Pfister, Roman (2023). Epidemiology of cardiac amyloidosis in Germany: a retrospective analysis from 2009 to 2018. Clin. Res. Cardiol., 112 (3). S. 401 - 409. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Background Improved imaging modalities contributed to increasing awareness of cardiac amyloidosis. Contemporary data on frequency trends in Germany are lacking. Methods In a retrospective study using health claims data of a German statutory health insurance, patients with diagnostic codes of amyloidosis and concomitant heart failure between 2009 and 2018 were identified. Results Prevalence increased from 15.5 to 47.6 per 100,000 person-years, and incidence increased from 4.8 to 11.6 per 100,000 person-years, with a continuous steepening in the slope of incidence trend. In patients with amyloidosis and heart failure age and proportion of men significantly increased, whereas the frequency of myeloma and nephrotic syndrome significantly decreased over time. Median (IQR) survival time after first diagnosis was 2.5 years (0.5-6 years), with a 9% (95% CI 2-15%, p = 0.008) reduced risk of death in the second compared to the first 5 years of observation. In the 2 years prior and 1 year after diagnosis, mean total health care costs were 6568 euro, 11,872 euro and 21,955 euro per person and year. Conclusion The rise in cardiac amyloidosis has continuously accelerated in the last decade. Considering the adverse outcome and high health care burden, further effort should be put on early detection of the disease to implement available treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ney, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Ihle, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhnke, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gunster, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Seuthe, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669972
DOI:	10.1007/s00392-022-02114-y
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	112
Number:	3
Page Range:	S. 401 - 409
Date:	2023
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEALTH-INSURANCE; HEART-FAILURE; DIAGNOSIS; PHENOTYPE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66997