Universität zu Köln

Fraemke, Annika, Ferrari, Nina, Friesen, David, Haas, Fabiola, Klaudius, Marlen, Mahabir, Esther, Schmidt, Lisa and Joisten, Christine (2022). HOMA Index, Vitamin D Levels, Body Composition and Cardiorespiratory Fitness in Juvenile Obesity: Data from the CHILT III Programme, Cologne. Int. J. Environ. Res. Public Health, 19 (4). BASEL: MDPI. ISSN 1660-4601

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Abstract

Juvenile obesity is associated with insulin resistance, among other comorbidities. In the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes, Vitamin D deficiency is very common. Therefore, the relationship between insulin resistance, body composition, vitamin D level, and cardiorespiratory fitness in obese children and youth were analyzed based on the Children's Health InterventionaL Trial III project, Germany. Data on vitamin D levels and homeostatic model assessment (HOMA) indices were available from 147 participants (52.4% female; 90.5% obese; 12.3 +/- 2.3 years, BMI: 30.5 +/- 5.2 kg/m(2), BMI standard deviation score (BMI-SDS): 2.52 +/- 0.46). Vitamin D levels correlated negatively with the HOMA index, BMI, BMI-SDS, abdominal circumference, and body fat percentage but positively with relative cardiorespiratory fitness (p < 0.05 in each case). In the backward stepwise linear regression analysis, body fat (in kg; beta = 0.403) and vitamin D levels (beta = -0.154) explained 21.0% of the variance in the HOMA index. In summary, increased body fat and lower vitamin D levels are associated with increased HOMA indices in overweight and obese children and adolescents. In order to prevent potential negative consequences, including the development of manifest Type 2 diabetes, a healthy lifestyle with a vitamin-D-enriched diet and more time spent outdoors should be promoted.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fraemke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrari, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Friesen, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Fabiola UNSPECIFIED UNSPECIFIED UNSPECIFIED Klaudius, Marlen UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahabir, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670345
DOI:	10.3390/ijerph19042442
Journal or Publication Title:	Int. J. Environ. Res. Public Health
Volume:	19
Number:	4
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-4601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 25-HYDROXYVITAMIN D LEVELS; MUSCULAR STRENGTH; ADOLESCENTS; CHILDREN; RISK; ASSOCIATION; ADIPOSITY; EQUATIONS; FAT Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67034