Universität zu Köln

Esser, Tobias, Zimmer, Philipp and Schier, Robert ORCID: 0000-0002-1846-4423 (2022). Preoperative exercise and prehabilitation. Curr. Opin. Anesthesiol., 35 (6). S. 667 - 674. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-6500

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Abstract

Purpose of review The purpose of this narrative review is to give an overview about the effects of multimodal prehabilitation and current existing and prospectively planned studies. The potential efficacy of exercise in the context of prehabilitation ranges from preoperatively improving patients' functional capacity to inducing cellular mechanisms that affect organ perfusion via endothelial regeneration, anti-inflammatory processes and tumour defense. Recent findings Current studies show that prehabilitation is capable of reducing certain postoperative complications and length of hospital stay in certain patient populations. These findings are based on small to mid-size trials with large heterogeneity, lacking generalizability and evidence that prehabilitation has positive effects on long term survival. The concept of prehabilitation contains the features, namely preoperative exercise, nutritional intervention and psychological support. Preoperative exercise holds potential molecular effects that can be utilized in the perioperative period in order to improve patients' postoperative outcome. Future multimodal prehabilitation trials must specifically clarify the clinical impact of this concept on patients' quality of life after major cancer surgery and cancer-specific survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Esser, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Schier, Robert UNSPECIFIED orcid.org/0000-0002-1846-4423 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670579
DOI:	10.1097/ACO.0000000000001188
Journal or Publication Title:	Curr. Opin. Anesthesiol.
Volume:	35
Number:	6
Page Range:	S. 667 - 674
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-6500
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CLINICAL-TRIAL; CANCER-SURGERY; PHYSICAL-FITNESS; INTERLEUKIN-6; OUTCOMES; PROGRAM; QUALITY; STATE; LIFE Multiple languages Anesthesiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67057