Universität zu Köln

Heinemann, Falko Markus, Lindemann, Monika ORCID: 0000-0001-6708-4390, Keles, Deniz, Witzke, Oliver, Kribben, Andreas, Baba, Hideo Andreas, Becker, Jan Ulrich, Heinold, Andreas, Horn, Peter Alexander and Eisenberger, Ute (2022). Cumulative mean fluorescent intensities of HLA specific antibodies predict antibody mediated rejections after kidney transplantation. HLA, 100 (6). S. 553 - 563. HOBOKEN: WILEY. ISSN 2059-2310

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Abstract

It is still not fully elucidated which pretransplant donor-specific HLA antibodies (DSA) are harmful after kidney transplantation. In particular, it needs to be clarified whether cumulative mean fluorescence intensities (MFI) against multiple HLA specificities have a predictive value for allograft function. Our retrospective single centre study analyzed preformed HLA antibodies determined by Luminex (TM) Single Antigen Bead (SAB) assay, including C1q addition, in relation to rejection and clinical outcome in 255 cross match negative kidney allograft recipients. Only 33 recipients (13%) of the total cohort showed early AMR during the first year posttransplant, but in patients with pre-transplant DSA the rate was increased to 15 out of 40 (38%). Three year graft survival was significantly shorter in patients with histological signs of AMR compared with patients without AMR or with no biopsy (74%, 92%, and 97%, respectively, p < 0.0001). In patients with HLA-DSA, a cumulative MFI value of all HLA antibodies of more than 103.000 indicated the highest risk for AMR posttransplant (p = 0.01). In conclusion, in patients with HLA-DSA, the cumulative MFI value may help to further stratify the risk of AMR after kidney transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heinemann, Falko Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindemann, Monika UNSPECIFIED orcid.org/0000-0001-6708-4390 UNSPECIFIED Keles, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Witzke, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribben, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Baba, Hideo Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Jan Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinold, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Peter Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenberger, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670593
DOI:	10.1111/tan.14790
Journal or Publication Title:	HLA
Volume:	100
Number:	6
Page Range:	S. 553 - 563
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2059-2310
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DONOR-SPECIFIC ANTIBODIES; CROSS-MATCH; CLINICAL-RELEVANCE; C1Q BINDING; CLASSIFICATION; DIAGNOSIS; RISK Multiple languages Cell Biology; Immunology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67059